등줄쥐에서의 한국형 출혈열 병원체 한탄바이러스의 전파경로 = Transmission of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, in Apodemus agrarius

다국어 초록 (Multilingual Abstract)

Epidemic hemorrhagic fever with renal syndrome was recognized for the first time in 1951 among UN troops in Korea. Since that time it has been known as Korean hemorrhagic fever (KHF) and remained endemic near the demilitarized zone between South and North Korea. In recent years it appears to have spread slowly in a southwesterly direction and about 800 hospitalized cases are clinically diagnosed each year.
In 1976 Lee and Lee succeeded in demonstrating an antigen in the lungs of the striped field mouse, apodemus agrarius, which gave specific iumunofluorescent reactions with sera from patients convalescent from KHF for the first time. The natural reservoir host of Korean hemorrhagic fever is Apodemus agrarius coreae in the rural endemic areas in Korea however, mode of transmission of Hantaan virus in Apodemus mice is not known to date yet.
This is the first report on demonstration of the mode of transmission of the virus experimentally in Apodemus agrarius.
1. Mice inoculated by the intramuscular route experienced viremia or about 5 days beginning on day 7. After 3 weeks, immunofluorescent and neutralizing antibodies were present and no mouse ever developed signs of acute illness.
2. Virus was recovered from lung, kidney, salivary gland, and liver, and virus excretion in urine, saliva, and feces occurred from about day 10 through day 640 (urine) postinoculation. Antigen, but not infectious virus, was persistent in lung tissue for as long as 1 year.
3. Horizontal contact infection occurred among cage-mates regardless of sexual pairing up to 640 days after infection and no evidence for participation of ectoparasitic arthropods in such transmission was obtained.