갈근 열수 추출물이 알루미늄을 투여한 흰쥐의 혈청 효소 활성도와 호르몬에 미치는 영향 = Effects of Water in Extracts of Pueraria Radix on Serum Enzymes Activities and Hormone in Aluminum-Administeredrats

다국어 초록 (Multilingual Abstract)

This study was designed to investigates the effects of Korean pueraris radix water extract in Al(Aluminum) administered rats. Forty-eight male Sprague-Dawley rats weighing 100±10g were used for this experiment and divided into following 6 groups; control group, 3% pueraria radix in water extract group, 1000 and 2000ppm Al group, 1000 and 2000ppm Al group with 3% pueraria radix in water extract group. The Al administered rats were given 1000 and 2000 ppm of Al₂(SO₄)₃ disolved in the distilled water. The Al content in the rats tissue of Al administered group was lower than in the rats tissue of AI group with 3% pueraria radix in water extract group. Plasma levels of renin and aldosterone activity was increased by Al administration group, compared with 3% pueraria radix in water extract group and Al administred group. Glutamate oxaloacetate transaminase(GOT) and Glutamate pyruvate transaminase(GPT) were increased in Al-administered group and lower in the 3% extracts of pueraria radix in water extract group. Lactate dehydrogenase(LDH) was lower in the 3% extracts of pueraria radix-Al group than in the Al group. This results suggested that pueraria radix in water extract group has a lowering effects on the accumulation of Al and it is belived that the pueraria radix in extracted water group has some protective effects to Al administered in rats, but the mechanism of these effects was obscure.

참고문헌 (Reference)

1 Takahashi K, "of isoflavonoids from thepueraria root" 250-254, 1988

2 Greger JL, "The toxicology of dietary tinaluminum and selenium" Academic pressNew York No 223 1987

3 Han SH, "The effects ofPuerariae radix catechins administration on liverfunction in carbon tetrachloride-treated rats" 24 : 713-720, 1995

4 Hayakawa J, "Studies onphysical and chemical quality evaluation of cruderadix and species puerarie" u (u): 50-56, 1984

5 Smith DR, "Stable isotropic traces of leadmobilized by DMZA chelation in low lead-exposedrats" 116 : 85-90, 1992

6 Smith DR, "Stable isotropic trace of leadmobilized by DMSA chelation in low lead-exposedrats" 116 : 85-90, 1992

7 Klein GL, "Nutritional aspects of aluminium toxicity" 3 : 117-141, 1990

8 Sato T, "Mechanism of antioxidant action of pueriaglycoside" axantho (axantho): 721-724, 1992

9 Graziano JH, "Influence of 2" lolaco (lolaco): 525-530, 1990

10 Crapper DR, "Experimental and clinicalneurotoxicology" 22 : 326-335, 1986

11 Sedman AB, "Encephalopathy inchildhood secondary to aluminum toxocity" 835-838, 1984

12 Cantilena LR, "Decreased effectivenessof chelation theraphy with time after acute cadiumpoisoning" 63 : 173-180, 1982

13 Klassen CD, "Decreased effectivenessof chelation theraphy with after actue cadmium120 韓國食生活文化學會誌 Vol" 173-180, 20051982

14 Keung WM, "Daidzin a potent selectiveinhibitor of human mitochondria aldehydedehydrogenase proc" 90 : 1247-1251, 1993

15 Kitagawa I, "Chemical studies on crude drug processing X Onthe constituents of rehamanniae radix comparisonof the constituents of various rehmanniae radixoriginzting in China" 992-115 1003, 1995

16 Lee SJ, "Bonchokangmok" 18 : 110-116, 1990

17 Keung WM, "Biochemical studies of anew class of alcohol dehydrogenase inhibition frompueriae radix" 17 : 1254-1260, 1993

18 Andreoil SP, "Aluminumintoxication from aluminum-containing phospahtebinders in children with azotemia not undergoimgdialysis" 1079-1084, 1984

19 Committee on nutrition, "Aluminum toxicity ininfants and children" 78 : 1150-1160, 1986

20 Alfrey AC, "Aluminum" 23 : 69-91, 1983

21 Krschbaum BB, "Acute aluminumtoxicity associated with oral citrate and aluminum-containg antacids" 297 : 9-11, 1989