A work-relatedness assessment in epidemiological case investigation of occupational cancers: II. Practice: an upper urinary tract cancer in a dyer

다국어 초록 (Multilingual Abstract)

An epidemiological case investigation of occupational cancer is conducted to determine the causation between the cancer and the worker's job. This review describes the overall process of work-relatedness assessment of the epidemiological case investigation through a case of upper urinary tract cancer (UUTC) in benzidine exposed worker in dyeing industry. Medical referrals, occupational history, material safety data sheet, and working environment monitoring submitted by the Korea Workers' Compensation and Welfare Service were reviewed. We further investigated literatures about the cotton dyeing industry, the domestic law and working environment monitoring reports. Benzidine was listed as an International Agency for Research on Cancer risk factor only for bladder cancer among urinary tract cancers, requiring different logical grounds for establishing causation. A literature review was conducted on the metabolic pathways of benzidine to establish biological plausibility. In addition, several papers were investigated that UUTC and bladder cancer share risk factors to extrapolate the epidemiological studies of bladder cancer. Epidemiologic studies of benzidine and bladder cancer were investigated. The worker is a 71-year-old man and performed dyeing and transporting at several dyeing factories for 29 years. The worker was diagnosed with UUTC based on radiologic and histologic results. It was critical to consider that he worked as a dyer for 3 years. The cancer was diagnosed in 2018, with a latent period of approximately 35 years. The worker performed cotton dyeing, and benzidine-based dye was mainly used. The quantitative exposure level of benzidine was reported from non-detection to 397.4 µg/m3 . In biological metabolisms, N-acetylhydroxylamine changes DNA structure of urothelium. As a result of reviewing 4 epidemiological studies, the standardized incidence ratio and standardized mortality ratio were significantly high with 3 years of exposure. Work-relatedness was finally assessed as probable based on biological mechanisms and epidemiological evidence. This review will help solutions for work-relatedness assessment processes.

참고문헌 (Reference)

1 Mazeman E, "Tumors of the upper excretory urinary tract, calices, renal pelvis and ureter" 78 : 1-219, 1972

2 Kirkali Z, "Transitional cell carcinoma of the ureter and renal pelvis" 47 (47): 155-169, 2003

3 Park DW, "The protocol for work-relatedness of worker diseases"

4 Jensen OM, "The Copenhagen case-control study of renal pelvis and ureter cancer : role of smoking and occupational exposures" 41 (41): 557-561, 1988

5 You XY, "Studies on the relation between bladder cancer and benzidine or its derived dyes in Shanghai" 47 (47): 544-552, 1990

6 Wilson RT, "Shared occupational risks for transitional cell cancer of the bladder and renal pelvis among men and women in Sweden" 51 (51): 83-99, 2008

7 Miyakawa M, "Re-evaluation of the latent period of bladder cancer in dyestuff-plant workers in Japan" 8 (8): 423-430, 2001

8 Wallace DM, "Occupational urothelial cancer" 61 (61): 175-182, 1988

9 Ministry of Employment and Labor, "Occupational safety and health act. Enforcement ordinance: article 29. A presidential decree"

10 Charbotel B, "Occupational exposures in rare cancers : a critical review of the literature" 90 (90): 99-134, 2014

11 Golka K, "Occupational exposure and urological cancer" 21 (21): 382-391, 2004

12 Schulte PA, "Occupational cancer of the urinary tract" 2 (2): 85-107, 1987

13 Korean Society of Occupational and Environmental Medicine, "Occupational and Environmental Medicine" Gyechuk Press 2014

14 Pukkala E, "Occupation and cancer-follow-up of 15 million people in five Nordic countries" 48 (48): 646-790, 2009

15 "National Toxicology Program. Benzidine and dyes metabolized to benzidine, report on carcinogens" National Institute of Environmental Health and Safety 2016

16 Montanaro F, "Mortality in a cohort of tannery workers" 54 (54): 588-591, 1997

17 Jung I, "Molecular mechanisms and pathways in bladder cancer development and progression" 7 (7): 325-334, 2000

18 International Agency for Research on Cancer, "List of classifications by cancer sites with sufficient or limited evidence in humans, volumes 1 to 123" International Agency for Research on Cancer 2018

19 International Agency for Research on Cancer, "IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Volume 99. Some aromatic amines, organic dyes, and related exposures"

20 International Agency for Research on Cancer, "IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans 100F-formaldehyde"

21 International Agency for Research on Cancer, "IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans 100F-benzidine"

22 Kim TG, "History of the synthetic dye industry" Textile Material Solution Center 2012

23 Shinka T, "Factors affecting the occurrence of urothelial tumors in dye workers exposed to aromatic amines" 2 (2): 243-248, 1995

24 Yeom HK, "Evaluation of dermal measurement for workers in benzidine dihydrochloride and benzidine based dye manufacturing factory" 10 (10): 83-93, 1998

25 Rouprêt M, "European association of urology guidelines on upper urinary tract urothelial carcinoma : 2017 update" 73 (73): 111-122, 2018

26 Soria F, "Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC)" 35 (35): 379-387, 2017

27 Kim Y, "Dye-manufacturing workers and bladder cancer in South Korea" 81 (81): 381-384, 2007

28 Korea Textile Inspection & Testing Institute, "Dye chemistry for dyeing technician: cellulose fiber dye (1)" Korea Textile Inspection & Testing Institute 2011

29 Fadl-Elmula I, "Cytogenetic analysis of upper urinary tract transitional cell carcinomas" 115 (115): 123-127, 1999

30 Rigola MA, "Comparative genomic hybridization analysis of transitional cell carcinomas of the renal pelvis" 127 (127): 59-63, 2001

31 Hamasaki T, "Clinical study of occupational uroepithelial cancer" 18 (18): 247-259, 1996

32 McLaughlin JK, "Cigarette smoking and cancers of the renal pelvis and ureter" 52 (52): 254-257, 1992

33 Naito S, "Cancer occurrence among dyestuff workers exposed to aromatic amines. A long term follow-up study" 76 (76): 1445-1452, 1995

34 Bulbulyan MA, "Cancer incidence and mortality among beta-naphthylamine and benzidine dye workers in Moscow" 24 (24): 266-275, 1995

35 Meigs JW, "Bladder tumor incidence among workers exposed to benzidine : a thirty-year follow-up" 76 (76): 1-8, 1986

36 Kim SA, "Bladder cancer with exposure to benzidine-based dyes of dyer" 11 (11): 304-312, 1999

37 Roh JH, "Benzidine exposure among benzidine-based dye manufacturing workers" 7 (7): 347-353, 1995

38 Kim EA, "Benzidine and occupational bladder cancer" Korea Industrial Health Association 2010

39 Oh SM, "A study on the exposure concentration and countermeasures of workers handling benzidine hydrochloride" Korea Occupational Safety and Health Agency 1994

40 Lim JH, "A guideline for evaluating work-relatedness of occupational cancer"

41 Kim KH, "A case study and case analysis of occupational cancer convalescence decision" Korea Workers' Compensation and Welfare Service 2019

42 Health Insurance Review & Assessment Service, "2018 National health insurance statistical yearbook" Health Insurance Review & Assessment Service 2018