Development of an Oral Immunoadjuvant from Cheonggukjang that is Efficacious for Both Mucosal and Systemic Immunity

다국어 초록 (Multilingual Abstract)

Immunological properties of a 50% ethanol/aqueous extract of cheonggukjang (CGJ), a fermentedsoybean product, were investigated as a potent, orallyavailable,and cost-effective immunoadjuvant. Differentfrom cholera toxin, a widely used experimental oral adjuvantwith effects limited to mucosal immunity in the gut, oraladministrationof the CGJ extract had positive effects onboth mucosal and systemic immunity. Administration ofkeyhole limpet hemocyanin (KLH) with the CGJ extractresulted in hyper-production of KLH-specific IgA in thegut and KLH-specific IgG in the serum. Oral-administrationof the CGJ extract resulted in promotion of both Th1 andTh2 immune responses, thus eliminating concerns over animbalanced Th1 and Th2 immune bias that is oftenobserved upon administration of other commonly usedimmunoadjuvants. Ethanol/aqueous extraction of CGJresulted in enrichment of polyphenolic compounds, includingflavonoids, providing a potential extra health benefit.

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