스펙트럼영역 빛간섭단층촬영기를 이용한 정상인의 황반부 측정치와 측정의 반복성 및 재현성 = The Measurements of Macular Thickness and Volume with SD-OCT in Normal Eyes

다국어 초록 (Multilingual Abstract)

Purpose: We investigated reproducibility and repeatability of average macular thickness and volume measurements in normal eyes with Cirrus HD OCT (optical coherence tomography). Methods: Fifty normal eyes from twenty-five subjects without medical and ocular histories were included. Macular cube 512 × 128 combination scanning using the Cirrus HD OCT was performed for a total of three times on the same visit by an experienced technician. Then other two technicians performed one more macular scanning respectively. Within-results, the intraclass correlation coefficient (ICC) was calculated for each parameter studied to evaluate repeatability and reproducibility. The correlation between macular measurements and demographic variables (age, gender, and spherical equivalent) were also investigated. Results: The ICCs for intraoperator reproducibility were 0.99 on the average macular thickness and 0.96 on the macular volume. And the ICCs for interoperator repeatability were found to be 0.98 and 0.96, respectively. The ICCs for measurements of nine regional retinal thickness also were higher than 0.90. The retinal thickness was correlated with age, gender and refractive error. However, neither age nor refractive error affected to reproducibility and repeatability. Conclusions: The retinal thickness and macular volume measurements using Cirrus HD OCT in healthy volunteers showed excellent reproducibility and repeatability. Therefore, Cirrus HD OCT has been recognized as an useful tool for diagnosis and mornitoring of variable maculopathies. J Korean Ophthalmol Soc 2011;52(10):1182-1188

참고문헌 (Reference)

1 신재호, "한국인에서 빛간섭단층촬영으로 측정한 중심와 두께와 안축장 및 굴절력과 관계" 대한안과학회 46 (46): 701-706, 2005

2 오세범, "정상인에서 시간 도메인과 스펙트럼 도메인 빛간섭단층촬영으로 측정한 황반두께 측정의 반복성 및 일치도" 대한안과학회 50 (50): 710-716, 2009

3 고병우, "정상안과 황반질환 안의 퓨리에 도메인과 시간 도메인 빛간섭단층촬영에 의한 황반두께 비교" 대한안과학회 50 (50): 1661-1668, 2009

4 문성운, "시간영역과 스펙트럼영역 빛간섭단층촬영기의 황반두께 측정치 및 반복성의 비교" 대한안과학회 50 (50): 1050-1059, 2009

5 Ooto S, "Three-dimensional profile of macular retinal thickness in normal Japanese eyes" 51 : 465-473, 2010

6 Kiernan DF, "Spectral-domain optical coherence tomography: a comparison of modern high-resolution retinal imaging systems" 149 : 18-31, 2010

7 Salyer DL, "Sexual dimorphism and aromatase in the rat retina" 126 : 131-136, 2001

8 Massin P, "Retinal thickness in healthy and diabetic subjects measured using optical coherence to mography mapping software" 12 : 102-108, 2002

9 Kanai K, "Retinal thickness and changes with age" 106 : 162-165, 2002

10 Kashani AH, "Retinal thickness analysis by race, gender, and age using stratus OCT" 149 : 496-502, 2010

11 Panda-Jonas S, "Retinal photoreceptor density decreases with age" 102 : 1853-1859, 1995

12 Huang J, "Retina" 29 : 980-987, 2009

13 Menke MN, "Reproducibility of retinal thickness measurements in healthy subjects using spectralis optical coherence tomography" 147467-147472, 2009

14 Hsu SY, "Reproducibility of peripapillary retinal nerve fiber layer and macular retinal thickness measurements using optical coherence tomography" 22 : 447-451, 2006

15 Syc SB, "Reproducibility of highresolution optical coherence tomography in multiple sclerosis" 16 : 829-839, 2010

16 Maldonado MJ, "Repeatability and reproducibility of posterior corneal curvature measurements by combined scanning-slit and placido-disc topography after LASIK" 113 : 1918-1926, 2006

17 Muscat S, "Repeatability and reproducibility of macular thickness measurements with the Humphrey OCT system" 43 : 490-495, 2002

18 Wong AC, "Relationship of gender, body mass index, and axial length with central retinal thickness using optical coherence tomography" 19 : 292-297, 2005

19 Kiernan DF, "Prospective comparison of cirrus and stratus optical coherence tomography for quantifying retinal thickness" 147 : 267-275, 2009

20 Guedes V, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes" 110 : 177-189, 2003

21 Legarreta JE, "Macular thickness measurements in normal eyes using spectral domain optical coherence tomography" 39 : 43-49, 2008

22 Early Treatment Diabetic Retinopathy Study Research Group, "Early Treatment Diabetic Retinopathy Study report number" 103 : 1796-1806, 1985

23 Han IC, "Comparison of spectral- and time- domain optical coherence tomography for retinal thickness measurements in healthy and diseased eyes" 147 : 847-858, 2009

24 Sayanagi K, "Comparison of retinal thickness measurements between three-dimensional and radial scans on spectral-domain optical coherence tomography" 148 : 431-438, 2009

25 Leung CK, "Comparison of macular thickness measurements between time domain- and spectral domain- optical coherence tomography (OCT)" 49 : 4893-4897, 2008

26 Polito A, "Comparison between retinal thickness analyzer and optical coherence tomography (OCT) for assessment of foveal thickness in eyes with macular disease" 134 : 240-251, 2002

27 Keane PA, "Accuracy of retinal thickness measurements obtained with Cirrus optical coherence tomography" 93 : 1461-1467, 2009

28 Müller R, "A critical discussion of intraclass correlation coefficients" 13 : 2465-2476, 1994