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      Host-Pathogen Interactions in Urinary Tract Infections

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      https://www.riss.kr/link?id=A106480880

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      다국어 초록 (Multilingual Abstract)

      Urinary tract infections (UTIs) are classified by the host condition. Uncomplicated infections are caused most commonly by uropathogenic Escherichia coli (UPEC) and affect otherwise healthy people, whereas complicated infections are com-monly caused by species, such as Proteus mirabilis, and affect patients with under-lying difficulties, such as a urinary tract abnormality or catheterization. The outcome of infection caused by these bacteria is dictated by the immune response to the UTI and the host factors that influence the susceptibility to disease. This review focuses on the host pathogen interactions in UTI, including an identification of additional virulence factors and therapeutic or prophylactic targets, particularly by UPEC and P. mirabilis.
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      Urinary tract infections (UTIs) are classified by the host condition. Uncomplicated infections are caused most commonly by uropathogenic Escherichia coli (UPEC) and affect otherwise healthy people, whereas complicated infections are com-monly caused b...

      Urinary tract infections (UTIs) are classified by the host condition. Uncomplicated infections are caused most commonly by uropathogenic Escherichia coli (UPEC) and affect otherwise healthy people, whereas complicated infections are com-monly caused by species, such as Proteus mirabilis, and affect patients with under-lying difficulties, such as a urinary tract abnormality or catheterization. The outcome of infection caused by these bacteria is dictated by the immune response to the UTI and the host factors that influence the susceptibility to disease. This review focuses on the host pathogen interactions in UTI, including an identification of additional virulence factors and therapeutic or prophylactic targets, particularly by UPEC and P. mirabilis.

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      참고문헌 (Reference)

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      6 Terlizzi ME, "UroPathogenic Escherichia coli(UPEC)infections : virulence factors, bladder responses, antibiotic, and non-antibiotic antimicrobial strategies" 8 : 1566-, 2017

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      8 Flores-Mireles AL, "Urinary tract infections : epidemiology, mechanisms of infection and treatment options" 13 : 269-284, 2015

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      10 Kosikowska P, "Urease inhibitors as potential drugs for gastric and urinary tract infections : a patent review" 21 : 945-957, 2011

      1 Nielubowicz GR, "Zinc uptake contributes to motility and provides a competitive advantage to Proteus mirabilis during experimental urinary tract infection" 78 : 2823-2833, 2010

      2 Alamuri P, "Vaccination with proteus toxic agglutinin, a hemolysin-independent cytotoxin in vivo, protects against Proteus mirabilis urinary tract infection" 77 : 632-641, 2009

      3 Wu XR, "Uroplakins in urothelial biology, function, and disease" 75 : 1153-1165, 2009

      4 Ulett GC, "Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection" 16 : 100-107, 2013

      5 Lloyd AL, "Uropathogenic Escherichia coli suppresses the host inflammatory response via pathogenicity island genes sisA and sisB" 77 : 5322-5333, 2009

      6 Terlizzi ME, "UroPathogenic Escherichia coli(UPEC)infections : virulence factors, bladder responses, antibiotic, and non-antibiotic antimicrobial strategies" 8 : 1566-, 2017

      7 Stamm WE, "Urinary tract infections: disease panorama and challenges" 183 (183): S1-S4, 2001

      8 Flores-Mireles AL, "Urinary tract infections : epidemiology, mechanisms of infection and treatment options" 13 : 269-284, 2015

      9 McLellan LK, "Urinary tract infection : pathogenesis and outlook" 22 : 946-957, 2016

      10 Kosikowska P, "Urease inhibitors as potential drugs for gastric and urinary tract infections : a patent review" 21 : 945-957, 2011

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      16 Johnson JR, "The IrgA homologue adhesin Iha is an Escherichia coli virulence factor in murine urinary tract infection" 73 : 965-971, 2005

      17 Raffi HS, "Tamm-horsfall protein protects against urinary tract infection by proteus mirabilis" 181 : 2332-2338, 2009

      18 Rather PN, "Swarmer cell differentiation in Proteus mirabilis" 7 : 1065-1073, 2005

      19 Wright KJ, "Sticky fibers and uropathogenesis : bacterial adhesins in the urinary tract" 1 : 75-87, 2006

      20 Mike LA, "Siderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infection" 113 : 13468-13473, 2016

      21 Guyer DM, "Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells" 70 : 4539-4546, 2002

      22 Huttner A, "Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection : a randomised, single-blind, placebo-controlled phase 1b trial" 17 : 528-537, 2017

      23 Sabri M, "Roles of the extraintestinal pathogenic Escherichia coli ZnuACB and ZupT zinc transporters during urinary tract infection" 77 : 1155-1164, 2009

      24 Martinez JJ, "Requirement of Rho-family GTPases in the invasion of type 1-piliated uropathogenic Escherichia coli" 4 : 19-28, 2002

      25 Schwan WR, "Regulation of fim genes in uropathogenic Escherichia coli" 1 : 17-25, 2011

      26 Garcia EC, "Redundancy and specificity of Escherichia coli iron acquisition systems during urinary tract infection" 79 : 1225-1235, 2011

      27 Duell BL, "Recent insights into microbial triggers of interleukin-10 production in the host and the impact on infectious disease pathogenesis" 64 : 295-313, 2012

      28 Rice JC, "Pyelonephritic Escherichia coli expressing P fimbriae decrease immune response of the mouse kidney" 16 : 3583-3591, 2005

      29 Sosa V, "Proteus mirabilis isolates of different origins do not show correlation with virulence attributes and can colonize the urinary tract of mice" 152 : 2149-2157, 2006

      30 Jacobsen SM, "Proteus mirabilis biofilms and catheterassociated urinary tract infections" 2 : 460-465, 2011

      31 Belas R, "Proteus mirabilis ZapA metalloprotease degrades a broad spectrum of substrates, including antimicrobial peptides" 72 : 5159-5167, 2004

      32 Himpsl SD, "Proteobactin and a yersiniabactin-related siderophore mediate iron acquisition in Proteus mirabilis" 78 : 138-157, 2010

      33 Vigil PD, "Presence of putative repeat-in-toxin gene tosA in Escherichia coli predicts successful colonization of the urinary tract" 2 : e00066-, 2011

      34 Nielubowicz GR, "Outer membrane antigens of the uropathogen Proteus mirabilis recognized by the humoral response during experimental murine urinary tract infection" 76 : 4222-4231, 2008

      35 Taha Neto KA, "Oral vaccine(OM-89)in the recurrent urinary tract infection prophylaxis : a realistic systematic review with meta-analysis" 40 : 203-208, 2016

      36 Zhang G, "On the essentiality of lipopolysaccharide to Gram-negative bacteria" 16 : 779-785, 2013

      37 Kehl-Fie TE, "Nutritional immunity beyond iron : a role for manganese and zinc" 14 : 218-224, 2010

      38 Cestari SE, "Molecular detection of HpmA and HlyA hemolysin of uropathogenic Proteus mirabilis" 67 : 703-707, 2013

      39 Kostakioti M, "Molecular blueprint of uropathogenic Escherichia coli virulence provides clues toward the development of anti-virulence therapeutics" 3 : 592-594, 2012

      40 Armbruster CE, "Merging mythology and morphology : the multifaceted lifestyle of Proteus mirabilis" 10 : 743-754, 2012

      41 Aguiniga LM, "Lipopolysaccharide domains modulate urovirulence" 84 : 3131-3140, 2016

      42 Smith KD, "Iron metabolism at the host pathogen interface : lipocalin 2 and the pathogen-associated iroA gene cluster" 39 : 1776-1780, 2007

      43 Duell BL, "Innate transcriptional networks activated in bladder in response to uropathogenic Escherichia coli drive diverse biological pathways and rapid synthesis of IL-10 for defense against bacterial urinary tract infection" 188 : 781-792, 2012

      44 Flannery EL, "Identification of a modular pathogenicity island that is widespread among urease-producing uropathogens and shares features with a diverse group of mobile elements" 77 : 4887-4894, 2009

      45 Subashchandrabose S, "Host-specific induction of Escherichia coli fitness genes during human urinary tract infection" 111 : 18327-18332, 2014

      46 Nielubowicz GR, "Host-pathogen interactions in urinary tract infection" 7 : 430-441, 2010

      47 Hannan TJ, "Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection" 36 : 616-648, 2012

      48 Hagan EC, "Haem acquisition is facilitated by a novel receptor Hma and required by uropathogenic Escherichia coli for kidney infection" 71 : 79-91, 2009

      49 Nesta B, "FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections" 3 : e00010-e00012, 2012

      50 Lane MC, "Expression of flagella is coincident with uropathogenic Escherichia coli ascension to the upper urinary tract" 104 : 16669-16674, 2007

      51 Flores-Mireles AL, "EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice" 6 : 254ra127-, 2014

      52 Nagamatsu K, "Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection" 112 : E871-E880, 2015

      53 O’Brien VP, "Drug and vaccine development for the treatment and prevention of urinary tract infections" 4 : 1-42, 2016

      54 Hooton TM, "Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults : 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America" 50 : 625-663, 2010

      55 Lloyd AL, "Defining genomic islands and uropathogen-specific genes in uropathogenic Escherichia coli" 189 : 3532-3546, 2007

      56 Garcia TA, "Cytotoxic necrotizing factor 1 and hemolysin from uropathogenic Escherichia coli elicit different host responses in the murine bladder" 81 : 99-109, 2013

      57 Barnhart MM, "Curli biogenesis and function" 60 : 131-147, 2006

      58 Pearson MM, "Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility" 190 : 4027-4037, 2008

      59 Stickler DJ, "Clinical complications of urinary catheters caused by crystalline biofilms : something needs to be done" 276 : 120-129, 2014

      60 최재영, "Clinical Significance of Toll-Like Receptor and Toll-Like Receptor Blocker" 대한요로생식기감염학회 11 (11): 1-6, 2016

      61 Nicolle LE, "Catheter-related urinary tract infection" 22 : 627-639, 2005

      62 Subashchandrabose S, "Back to the metal age : battle for metals at the host-pathogen interface during urinary tract infection" 7 : 935-942, 2015

      63 Heimer SR, "Autotransporter genes pic and tsh are associated with Escherichia coli strains that cause acute pyelonephritis and are expressed during urinary tract infection" 72 : 593-597, 2004

      64 Thumbikat P, "Antigen-specific responses accelerate bacterial clearance in the bladder" 176 : 3080-3086, 2006

      65 Lima A, "An iron-regulated outer-membrane protein of Proteus mirabilis is a haem receptor that plays an important role in urinary tract infection and in in vivo growth" 56 : 1600-1607, 2007

      66 Spaulding CN, "Adhesive pili in UTI pathogenesis and drug development" 5 : E30-, 2016

      67 Alamuri P, "A novel autotransporter of uropathogenic Proteus mirabilis is both a cytotoxin and an agglutinin" 68 : 997-1017, 2008

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