전기자극의 강도와 측정전극의 간격이 감각신경신호의 파라미터에 미치는 영향 연구 = The Effects of the Stimulation Intensity and Inter-Electrode Distance on the Parameters of the Measured Sensory Nerve Signal

다국어 초록 (Multilingual Abstract)

This study was designed to investigate the effects of stimulation intensity and inter-electrode distance on the parameters of the measured sensory nerve signal. 30 healthy subjects participated in this study. Sensory nerve signals were elicited by four different pulse amplitudes, i.e., 3, 6, 9, 12 mA, with the pulse width fixed at $500{\mu}s$. The sensory nerve signals elicited by the four different pulse amplitudes were measured by four different inter-electrode distances (20, 30, 40, and 50 mm). We extracted four parameters (pulse amplitude, pulse width, pulse area, and latency time from stimulation) from the sensory nerve signals. The measured pulse amplitude and pulse width were increased when the measuring inter-electrode distance was increased while the stimulating pulse amplitude was fixed. The measured pulse amplitude was saturated with the stimulating pulse amplitudes of over 6 mA while measuring inter-electrode distance. Under the same condition, measured pulse width was increased, and sensory nerve signal was initiated early. Sensory nerve signals, specially those of pulse amplitude, were distorted by a differential amplification method that commonly measures the human body signal. The experimental results indicate that the differential amplification method is required to be replaced when measuring nerve signals. Our observations suggested that the hyperpolarization of the action potential of the sensory nerve signal for preventing distortion could be used to clarify the correlation between the parameters of the sensory nerve signals and quantification of sensations.

참고문헌 (Reference)

1 Dawson GD., "The Recording of Nerve Action Potentials Through Skin in Man" 12 (12): 295-267, 1949

2 Eduardo E., "The Optimal Recording Electrode Configuration for Compound Sensory Action Potentials" 51 (51): 684-687, 1988

3 Nashed J., "The Consequences of Stimulus Intensity on Sensory Nerve Action Potentials" 1 (1): 108-115, 2009

4 Wiederholt WC, "Stimulus Intensity and site of Excitation in Human Median Nerve Sensory Fibers" 33 (33): 438-441, 1970

5 Gilliatt RW., "Sensory Nerve Action Potentials in Patients with Peripheral Nerve Lesions" 21 (21): 295-267, 1949

6 Strange KD., "Restoration of Use of Paralyzed Limb Muscles Using Sensory Nerve Signals for State Control of FES-Assisted Walking" 7 (7): 289-300, 1999

7 Evanoff V Jr., "Optimal Interelectrode Distance in Sensory and Mixed Compound Nerve Action Potentials : 3-Versus 4-Centimeter Bar Electrodes" 85 (85): 405-408, 2004

8 Dawson GD, "Investigations on a Patient Subject to Myo-clonic Seizures after Sensory Stimulation" 10 (10): 141-162, 1947

9 Ven AA., "Effect of size and pressure of surface recording electrodes on amplitude of sensory nerve action potentials" 30 (30): 234-238, 2004

10 Plastaras CT., "Effect of interelectrode distance on sural nerve action potential parameters" 87 (87): 183-188, 2008

11 Yoo JK., "Comparison of Weighted Needle Pinprick Sensory Thresholds and Sensory Nerve Conduction Studies in Diabetic Patients" 28 : 899-910, 1995