Flow Cytometric DNA Content Study on Uterine Leiomyomatous Tumors

다국어 초록 (Multilingual Abstract)

Flow cytometric DNA content analysis of 21 cases of benign leiomyomas, 2 cases of symplastic leiomyomas, 1 case of atypical leiomyoma, 1 case of borderline malignancy of leiomyoma and 3 cases of leiomyosarcomas with paraffin blocks from uterine hysterectomy specimen were performed. Only two cases out of 21 cases of benign leiomyomas (9 %) showed aneuploid patterns, one out of three leiomyosarcomas was aneuploidy and all others were diploidy. In histograms, the only G2 + M/G1 ratio fraction showed significant differences between benign leiomyomas and other symplastic, atypical leiomyomas, borderline malignancy of leiomyoma and leiomyosarcomas (P < 0.05). In histogramic fractions between benign and non-benign tumors, there were very significant differences in Go + M/Gi ratio (P < 0.001). There were no differences in ploidy pattern, Go/G1 fraction; S phase fraction, G2 + M fraction, prolifereation index and DNA index. Between benign leiomyomas and leiomyosarcomas, in cases of diploid tumors, only G2 + M/G1 ratio showed significant difference (P < 0.05) and in cases of aneuploid tumors, there was only suggestion of difference in only Go/G1 fraction.