<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>This study evaluated the synergetic effect between surface pre-reacted glass-ionomer (SPRG) filler and 2-methacryloyloxyethyl phosphorylcholine (M...
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https://www.riss.kr/link?id=A107744575
2019
-
SCOPUS,SCIE
학술저널
1331-1341(11쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>This study evaluated the synergetic effect between surface pre-reacted glass-ionomer (SPRG) filler and 2-methacryloyloxyethyl phosphorylcholine (M...
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>This study evaluated the synergetic effect between surface pre-reacted glass-ionomer (SPRG) filler and 2-methacryloyloxyethyl phosphorylcholine (MPC), for inhibiting multi-species biofilm formation, while maintaining or even improving the original beneficial features of SPRG-filled resin-based composite (RBC).</P> <P><B>Methods</B></P> <P>MPC (1.5–10wt%) was incorporated into commercial SPRG-filled RBC. Then, the inherent properties of RBC, and ion release and acid-neutralising properties associated with SPRG were investigated. Further, protein adsorptions and bacterial adhesion and viability on the SPRG-filled RBC surfaces were studied using four kinds of oral bacteria; <I>Streptococcus mutans</I>, <I>Actinomyces naeslundii</I>, <I>Veillonella parvula</I>, and <I>Porphyromonas gingivalis</I>. Finally, the thickness and biomass of the human saliva-derived biofilm model cultured on test and control samples were analysed.</P> <P><B>Results</B></P> <P>Addition of MPC content resulted in decreased flexural strength and wettability of SPRG-filled RBC. SPRG-filled RBC released significantly higher amounts of multiple ions as contents of MPC increased. Meanwhile, SPRG-filled RBC with 5-wt% MPC significantly improved acid-neutralising properties than those of other test and control samples (<I>P</I> <0.001). SPRG-filled RBC with 3wt% MPC significantly reduced the amount of adsorbed bovine serum albumin and proteins from the brain heart infusion medium as compared to the control (<I>P</I> <0.01). A similar trend was observed in the attachment of four types of bacteria and multi-species biofilm (<I>P</I> <0.01).</P> <P><B>Significance</B></P> <P>Despite limitation in terms of deteriorations of some physical properties, addition of 3% MPC to SPRG-filled RBC leads to inhibition of the attachment of multi-species bacteria on its surface, as well as inhibition of biofilm growth. Moreover, the original important bioactive features of SPRG-filled RBC such as ion release and acid neutralisations are either maintained or improved upon adding MPC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A zwitterionic material (MPC, 1.5–10%) is added to commercial SPRG-filled RBC. </LI> <LI> Addition of MPC result in deteriorations of physical properties. </LI> <LI> Sample with 3% MPC inhibits attachment of multispecies bacteria on its surface. </LI> <LI> Sample with 3% MPC inhibits biofilm growth. </LI> <LI> The ion release and acid neutralisations were maintained or even improved with adding MPC. </LI> </UL> </P>