Poster Session：PS 0515 ; Nephrology : Examination of Involvement of the Autonomic Nervous Function as the Mechanism and Relevance of Association Between Renal Function and Changes in Blood Pressure During Sit-to-Stand Orthostatic Stress Test in Non-Diabet = Poster Session：PS 0515 ; Nephrology : Examination of Involvement of the Autonomic Nervous Function as the Mechanism and Relevance of Association Between Renal Function and Changes in Blood Pressure During Sit-to-Stand Orthostatic Stress Test in Non-Diabet

다국어 초록 (Multilingual Abstract)

Background: In late years, it`s been revealed that orthostatic hypotension (OH) is a risk factor associated with the onset of cardiovascular disease. It is considered that autonomic nervous dysfunction and arteriosclerosis are the important cause of OH. However, there are few reports of the association between atherosclerotic disease such as kidney disease and OH. Therefore, we evaluated the association between renal function and OH in non-diabetic patients. Methods: We studied 320 non-diabetic patients having arteriosclerosis risk factors such as hypertension and dyslipidemia. CAVI was measured as an index of arterial stiffness. We performed sit-to-stand orthostatic stress test to evaluate the association between blood pressure change, eGFR, and heart rate variability. Results: A signifi cant positive correlation was found between eGFR and orthostatic blood change both in systolic and diastolic blood pressure. There was a negative correlation between CAVI and eGFR. LF (low frequency) at the rest state and eGFR tended to have a positive correlation, and a signifi cant positive correlation was found between LF at the standing state and eGFR. There were no signifi cant correlation between eGFR and orthostatic change in HF (high frequency) and LF/HF. In the multiple regression analysis, orthostatic change in systolic blood pressure had a significant correlation with gender, BMI and eGFR. Conclusions: Our results indicate that orthostatic blood pressure decline is associated with decreased renal function in non-diabetic patients. It was suggested that decreased renal function is an important risk factor of OH independent of arterial stiffness and autonomic nervous function.