P-88 Correlation between impaired lung function and PD-L1 expression in lung adenocarcinoma = P-88 Correlation between impaired lung function and PD-L1 expression in lung adenocarcinoma

다국어 초록 (Multilingual Abstract)

Purpose: The objective of the present study was to clarify whether the programmed death-ligand-1 (PD-L1) expression is associated with clinical characteristics including impaired lung function in lung adenocarcinoma.
Patients and methods: This was a retrospective study performed between September 2016 and May 2017 in Seoul St. Mary’s Hospital, Bucheon St. Mary’s Hospital, Incheon St. Mary’s Hospital and Uijeongbu St. Mary’s Hospital, The Catholic University of Korea. A total of 140 patients with lung adenocarcinoma were analyzed for PD-L1 by immunohistochemistry using the clone 22C3 PharmDx kit and evaluated to determine the association between PD-L1 expression and pulmonary function test.
Results: A PD-L1 tumor proportion score of at least ≥ 1% was seen in 60.0% of tumors. In a multivariate analysis, low diffusing capacity of the lung for carbon monoxide (DLCO) (Odds ration[OR]=5.829, 95% confidence intervals(CI)=1.337-25.42, P=0.019) and smoking pack-years (OR=1.051, 95% CI=1.016-1.088, P=0.005) were found to be associated with PD-L1 expression. However, chronic obstructive pulmonary disease or low forced expiratory volume 1 was not associated with PD-L1 expression.
Conclusion: low DLCO was associated with PD-L1 expression in lung adenocarcinoma.