Human albumin solutions which are used in medical and surgical conditions are required national lot release regulatory before releasing into the market. Testing for the albumin content is the key component and the Kjeldahl method, which can be time-co...
Human albumin solutions which are used in medical and surgical conditions are required national lot release regulatory before releasing into the market. Testing for the albumin content is the key component and the Kjeldahl method, which can be time-consuming processes and safety concerns regarding sulfuric acid use, is currently the official test method for albumin content in Ministry of Food and Drug Safety, Republic of Korea. In this study, we applied SoloVPE, a new UV-vis spectroscopic technology using a variable path length extension to quantify albumin content for quality control purposes regarding human albumin solution. With its validation, a strong correlation was shown between the Kjeldahl method and SoloVPE. Our findings can help improve the current testing methods for albumin content and provide better quality controls for human albumin solutions.