This study wes performed to investigate effectiveness on the gastritis and gastric lesion with the methanol extract of the flower buds of Eugenia caryophyllata. The extract was fraotionated with hexane, chlomform, ethyl acetate, butanol, followed by b...
This study wes performed to investigate effectiveness on the gastritis and gastric lesion with the methanol extract of the flower buds of Eugenia caryophyllata. The extract was fraotionated with hexane, chlomform, ethyl acetate, butanol, followed by bioassay on antigastritis. The ethyl acetate and the buthanol fraction reduced significantly HCl- ethanol induced gastric lesion at the dose of 165 and 215 mg/kg, p.o., respectively. These results may indicate that remarkably effective are ethyl acetate and butenol fractions in HCl-ethanol induced gastric lesion. However, the fractions didn't exhibit any inhibition of gastric secretion and acid output. The buthanol fraction reduced significantly the acetic acid induced ulcer at a daily dose of 215 mg/kg, p.o., given for 10 days. These result showed considerable inhibit of acetic add induced ulcer without inhibition of indomethacin induced gastric lesion. The methanol extract showed low acute toxicity with minimum lethal dose of more than 3000 mg/kg, p.o. in mice. In conclusion, Eugenia Flos exhibited antigastric activity which might be attributable to inhibition of gastric secretion. It is indicated that active component may be present in the buthanol fraction.