후두마스크 삽입시 allfentanil-propofol 병용투여와 propofol 단독투여의 비교 = The Comparison of Co-administration of Alfentanil-Propofol with Propofol in Insertion of Laryngeal Mask Airway

다국어 초록 (Multilingual Abstract)

Background: We performed a prospective, randomized, controlled trial to compare the quality, hemodynamic response, and recovery index of laryngeal mask airway (LMA) insertion after either propofol alone or co-administration of alfentanil-propofol anesthesia.
Methods: Sixty patients (ASA 1 or 2, 17-63 years) were randomly allocated to control and experimental group. Control group(Group I) was received placebo (saline), experimental groups were received alfentanil 10μg/kg (Group II), 20μg/kg (Group III), 30μg/kg (Group IV).
Results: Loss of consciousness and LMA insertion were more rapid in patients with alfentanil 30 μg/kg group than control group (P ＜ 0.05). In alfentanil 20μg/kg group, loss of consciousness was more rapid than control group. Also, there were significant differences in propofol induction dose, effect site concentration on induction, and propofol maintenance dose between control and experimental group (P ＜ 0.05).
Conclusions: We conclude that co-adminstration of alfentanil-propofol, especially 30μg/kg group, compares favorably with propofol alone, although LMA removal time is prolonged.

참고문헌 (Reference)

1 "The target plasma concentration of propofol required to insert a laryngeal mask airway without muscle relaxant use" 44 : 18-23, 2003

2 "Propofol alters the pharmacokinetics of alfentanil in healthy male volunteers" 94 : 949-57, 2001

3 "Pharmacodynamic interaction between propofol and alfentanil when given for induction of anesthesia" 84 : 288-99, 1996

4 "Oral clonidine premedication reduces propofol requirement for laryngeal mask airway insertion" 47 : 627-30, 2000

5 "Movements of the vocal cords on induction of anaesthesia with thiopentone or propofol" 69 : 661-2, 1992

6 "Mixed- effects modeling of the influence of alfentanil on propofol pharmacokinetics" 100 : 795-805, 2004

7 "Effects of combining propofol and alfentanil on ventilation and emesis in human volunteers" 23-37, 1996

8 "Edited by Miller RD" Churchill Livingstone intrave (intrave): 317-78, 2005

9 "Comparison of sevoflurane with propofol for laryngeal mask airway insertion in adults" 88 : 908-12, 1999

10 "Comparison of propofol and thiopentone for laryngeal mask insertion" 46 : 771-2, 1991

11 "Co- administration of alfentanil-propofol improves laryngeal mask airway insertion compared to propofol" 49 : 508-12, 2002

12 "Clinical interpretation of pharmacokinetic and pharmacodynamic propofol-opioid interactions" 52 : 445-51, 2001

13 "Anesthesia Induction with propofol using a target controlled infusion(TCI)" 34 : 944-50, 1998