ADR-β3와 PPAR-γ 유전자 변형이 일회성 운동강도에 따라 비만여성의 Leptin과 Insulin 변화에 미치는 영향 = The Effects of ADR-β3 and PPAR-γ Gene Mutation at Obese Women's Change of Amount of Leptin and Insulin by Exercise Intensity

다국어 초록 (Multilingual Abstract)

Subjects selected for this study were obese middle-aged women between 40 and 42, BMI 29 to 30. The subjects were divided into three groups. First, obese groups who have no influence of gene mutation (A group n=6). Second, β3-adrenergic receptor gene mutation groups (B group n=7). Third, groups who have two kinds of gene mutations, β3-adrenergic receptor (β3-AR) and PPAR-γ (C group n=6). This study is conducted on a treadmill and each group at 40~50%HRmaxㆍ50~60%HRmax and 60~70%HRmax about 80 minutes respectively. It is used a LatinSquare Design in order to examine the changes in Leptin and Insulin. Intending to establish the optimal exercise intensity by cause according to gene type of obesity. The main results of this study were as follow: The leptin and Insulin level showed significant differences in exercise period (p＜.001), and also in interaction between exercise period and group (p＜.01). The regardless of types and existence of genes and variation of strength of exercise, the walking which is representative of aerobic exercise can solve and protect the obesity.

목차 (Table of Contents)

• Abstract
• 1. 서론
• 2. 연구방법
• 3. 연구결과
• 4. 논의
• 5. 결론
• 인용문헌

참고문헌 (Reference)

1 Pelleymounter, M. A., 269 : 540-543, 2000

2 신순현, "임상비만학 제 2판" 고려의학 19-29, 2001

3 성혜련, "유산소운동이 인슐린 비의존형 당뇨병환자의 혈당 및 면역기능에 미치는 영향" 18 (18): 126-137, 1999

4 김창규, "유산소운동이 비만인의 혈청Leptin에 미치는 영향" (8) : 61-71, 2000

5 김선호, "유산소성 운동과 저항성 운동이 비만 여중생의 신체조정, 혈중지질, Leptin 및 Anabolic Hormone에미치는 영향" 전남대학교 대학원 2001

6 김상원, "운동프로그램이 비만아동의 Leptin, 혈중 지질, 유산소 능력 및 신체조성에 미치는 영향" 단국대학교 대학원 1999

7 김태형, "운동과 지방대사의 조절" 대한운동사회 89-97, 2003

8 왕석우, "비만유전자 변이 유·무가 Training과 Detraining 후 비만여성의 생리적 변화에 미치는 영향" 한양대학교 대학원 2002

9 이태진, "비만여대생의 비만유전자 조합 변이 유·무에 따른 유산소 운동이 혈중지질 및 건강관련 체력에 미치는 영향" 숙명여자대학교 대학원 2006

10 유병강, "강도별 복합운동이 비만여성의 체성분, 심폐기능, 혈중지질 및 혈중 호르몬에 미치는 영향" 한양대학교 대학원 2005

11 신창호, "β3아드레날린 수용체 유전자 다형성이 대사조절 호르몬과 신체구성에 미치는 영향" 서울대학교 대학원 2001

12 Walston, J., "Time of onset of non insulin dependent diabetes mellitus and genetic variation in the β3 adrenergic receptor gene" 33 : 343-347, 2005

13 Vidal, H., "The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue" 98 : 251-255, 2006

14 Bjorntorp, P., "The effects of exercise on plasma insulin" 2 : 125-129, 2001

15 Mikines, K. J., "The effect of acute exercise and detraining on insulin action in trained man" 66 : 704-711, 1998

16 Susulic, V., "Targeted disruption of the β3 adrenergic receptor gene" 270 : 29483-29492, 2005

17 Kohrt, W. M., "Serum leptin levelsare reduced in response to exercise training, but not hormonereplacement therapy, in older women" 81 : 3980-3985, 2004

18 Torjman, M., "Serum leptin during recovery following maximal incremental and prolonged exercise" 20 (20): 444-450, 1999

19 Zimmer, P., "Serum leptin concentration, obesity and insulin resistance in Westem Samoans" 313 : 965-969, 1999

20 Considine, R. V., "Serum immunoreactive leptin concertrations in normal weight and obese humans" 334 : 292-295, 2000

21 Fan, W., "Role of melanocortinergic neurons in feeding and the agouti obesity syndrome" 358 : 165-168, 2001

22 Kolaczynski, J. W., "Response of leptin to short-term andprolonged overfeeding in humans" 81 : 4162-5, 1999

23 Brent, E., "Renata Tenenbaum and Rejeanne Gougeon (1999). Effect of prolonged moderate and severe energy restriction and refeeding on plasma leptin concentration on obese women" 70 : 321-330, 1999

24 Akira, H., "Relationship between concentration of serum leptin and fetal growth" 84 (84): 1716-1722, 2002

25 Ostlund, R. E., Jr., "Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates" 81 (81): 3909-3913, 2003

26 Duclos, M., "Rapid leptin decrease in immediate post-exercise recovery" 50 (50): 337-42, 1999

27 Zhang, Y., "Positional cloning of the mouse obese gene and its human homologue" 372 : 425-432, 2000

28 Yiying, Z., "Positional cloning of the mouse obese gene and its human homologue" 372 : 425-432, 2004

29 Gutin, B., "Plasma leptin concentration in obese children: Changes during period with and without physical training" 69 (69): 388-394, 1999

30 James, S. A., "Physical activity and NIDDM in African-Americans.Diabetes" 21 (21): 552-562, 2001

31 Collins, S., "Pharmacologic manipulation ob expression in adietary model of obesity.J.Biol" 271 : 9437-9440, 2003

32 Flier, J. S., "Obesity researtch springs a proton leak.Nature" 15 : 223-224, 2001

33 Durstine, J. L., "Lipids, lipoproteins, and exercise" J. Cardiopulm 2002

34 De Silva, A., "Lifestyle factors fail to explain the variation in plasma leptin concentration in women" 14 (14): 653-657, 1998

35 Marzo, V., "Leptin regulated endocannabinoids are involved in maintaining food intake" 410 : 822-825, 2001

36 Seufert, J., "Leptin inhibits insulingene transcription and reverse hyperinsulinemia in leptin~deficient ob/ob mice" 96 (96): 674-679, 1999

37 Reidy, S., "Leptin : an essential regulator of lipid metabolism" 125 : 285-297, 2000

38 Weltman, A., "Intensity of acute exercise does not affect serum leptin concentrations in young men" 32 (32): 1556-1561, 2000

39 Kuczmarski, R. J., "Increasing prevalence of overweight among US adults. the National Health and Nutrition Examination surveys, 1960 to 1991" 272 : 205-211, 2002

40 Arner, P., "Hunting for human obesity genes? Look in the adipose tissue!" 4 : S57-S62, 2000

41 Bouchard, C., "Genetics of obesity : Overview and research directions. in the genetics of obesity" 223-233, 2000

42 Corella, D., "Gender specific association of the Trp64Arg mutation in the beta3 adrenergic receptor gene with obesity related phenotypes in a mediterranean population : interaction with common lipoprotein lipase gene variation" 250 (250): 348-360, 2001

43 Hickey, M., "Gender differences in erum leptin levels in humans" 59 : 1-6, 2004

44 Zafeiridis, A., "Effects of prolonged exercise on leptin changes during exercise and recovery" The Temple University Graduate Board 2001

45 Okazaki, T., "Effects of mild aerobic exercise and a mild hypocaloric diet on plasma leptin in sedentary women" 26 (26): 415-420, 1999

46 Robert, G., "Effect on improvement in aerobic power on resting insulin and glucose concentrations in children" 81 : 132-139, 2000

47 Noland, R. C., "Effect of intense training on plasma leptin in male & female swimmers" 33 (33): 227-231, 2001

48 Olive, J. L., "Differential effects of maximaland moderate-intensity runs on plasma leptin in heathly trained subjects" 17 : 365-369, 2001

49 Essig, D., "Delayed effects of exercise on the plasma leptin concentration" 49 (49): 395-399, 2000

50 Caro, J., "Decreased cerebrospinal fluid serum leptin ratio in obesity : a possible mechnism for leptin resistance" 348 : 159-161, 2000

51 Ryan, A. S., "Changes in plasma leptin and insulin actin with resistance training in postmenopausal women" 24 (24): 27-32, 2000

52 Fujisawa, T., "Association of Trp64Arg mutation of the beta 3adrenergic receptor with NIDDM and body weight gain" 39 : 349-352, 2003

53 Eriksson, J., "Aerobic endurance exercise of circuit type resistance training for individual with impaired glucose tolerance" 30 (30): 37-41, 2002

54 Pagano, C., "Acute effects of exercise on circulating leptin in lean and genetically obese fa/fa rats" 255 : 698-702, 1999

55 Kadowaki, H., "A mutation in the β3 adrenergic receptor gene is associated with obesity and hyperinsulinemia Japan subjects" 215 : 555-560, 2005

56 Wang, J., "A Nutrient~sensing Pathway reguthway regulates leptin gene expression in muscle and fat" 393 : 684-688, 2000