<P>A new class of pH-<I>responsive multivalent host</I>–guest interactions to manipulate polypeptide-based nano-vehicles was developed. Poly(<SMALL>l</SMALL>-lysine) (poly(Lys)) grafted with β-cyclodextrin a...
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=A107547226
2014
-
SCI,SCIE,SCOPUS
학술저널
368-381(14쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>A new class of pH-<I>responsive multivalent host</I>–guest interactions to manipulate polypeptide-based nano-vehicles was developed. Poly(<SMALL>l</SMALL>-lysine) (poly(Lys)) grafted with β-cyclodextrin a...
<P>A new class of pH-<I>responsive multivalent host</I>–guest interactions to manipulate polypeptide-based nano-vehicles was developed. Poly(<SMALL>l</SMALL>-lysine) (poly(Lys)) grafted with β-cyclodextrin and 2,3-dimethylmaleic acid was coupled with oleic acid. This new polymer was utilized to fabricate pH-responsive nano-vehicles for antitumor drug doxorubicin delivery. The host–guest (zipping) interaction between β-cyclodextrin and 2,3-dimethylmaleic acid moieties and the hydrophobic interaction between the oleic acid molecules contributed to form self-assembled nano-vehicles. 2,3-Dimethylmaleic acid moieties were highly degradable at a slightly acidic pH (~pH 6.8). These nano-vehicles increased the release of the encapsulated doxorubicin content (by the unzipping interaction between β-cyclodextrin and degraded 2,3-dimethylmaleic acid moieties) when the pH of the solution decreased to 6.8. This event caused a significant increase in the efficiency of cellular doxorubicin uptake and in vitro tumor inhibition.</P>