비만(肥滿)과 Angiotensin 전환효소 DNA의 다형성과의 관련성 연구 = Studies on the Relationship between Obesity and Polymorphism in Angiotensin Converting Enzyme Gene

다국어 초록 (Multilingual Abstract)

Objecives : The aim of this study is to investigate the relationship between obesity and ACE gene polymorphism.Methods: The authors investigate ACE genotypes, Sasang Constitution, body mass index, total cholesterol, triglyceride, fat mass, percentage body fat, ratio of waist-to-hip in 95 obese patients and non-obese 589 controls, and analyze the relationship between obesity and ACE gene polymorphism by utilizing independent t-test, ANOVA test and Xsquare test, a statistical technique. Results : There was no significant difference in the frequencies of the ACE genotypes, and the authors did not find any association between ACE polymorphism and obesity. Also, the author classified the obese patients into four types according to Sasang Constitution, and examined the association between obesity and Sasang Constitution. As a result, the frequency of Taeumin was significantly higher in obese patients than in controls. Conclusions : These results indicate that the ACE polymorphism is not a risk factor for the development of obesity in Korean population. Furthermore, the authors first attempted to evaluate the efficacy of Sasang Constitution, and to find an association with obesity.