Poster Session : PS 0854 ; Upper GI Tract : Helicobacter pylori Eradication Rates with 10-Day Non- Bismuth Quadruple Therapy and 10-Day Sequential Therapy According to Clarithromycin Resistance in Korea = Poster Session : PS 0854 ; Upper GI Tract : Helicobacter pylori Eradication Rates with 10-Day Non- Bismuth Quadruple Therapy and 10-Day Sequential Therapy According to Clarithromycin Resistance in Korea

다국어 초록 (Multilingual Abstract)

Background: Since the effi cacy of the standard triple therapies for Helicobacter pylori ( H. pylori) eradication has decreased, novel antibiotic regimens have been introduced. The aim of this study was to compare the effi cacy of non-bismuth quadruple therapy with sequential therapy for the fi rst-line H. pylori eradication in Korea and to evaluate the effect of resistance to clarithromycin on the effi cacy of each treatment regimen. Methods: Fifty-fi ve patients with proven H. pylori infection using dual priming oligonucleotide (DPO)-PCR kit were randomly assigned to one of 2 regimens: amoxicillin 1000mg with clarithromycin 500 mg, metronidazole 500 mg, and pantoprazole 40mg twice daily for 10 days (non-bismuth quadruple therapy) or amoxicillin 1000mg with pantoprazole 40mg twice daily for 5 days followed by clarithromycin 500mg with metronidazole 500mg, and pantoprazole 40 mg twice daily for 5 days (sequential therapy). The success of H. pylori eradication was evaluated 4-5 weeks after completing treatment. Results: Eradication rates were 96.3% in the concomitant therapy and 81% in the sequential therapy (per protocol), but the difference was not statistically signifi cant (P = 0.153). Sixteen strains (29.1%) showed clarithromycin resistance. In mutant strains, the eradication rate was 68.8% (11/16) (ITT analysis) and the eradication rate of non-bismuth quadruple therapy was signifi cantly higher than sequential therapy (84.6% (11/13) vs. 0% (0/3), P=0.018). Conclusions: Non-bismuth quadruple therapy led to a non-statistically advantage over sequential therapy, especially in mutant strains in Korea.