전신성 홍반성 루푸스 환자의 사망원인 및 예후관련인자 = Causes of Death and Predictor Variables for Mortality in Korean Patients with Systemic Lupus Erythematosus

다국어 초록 (Multilingual Abstract)

Objective: To determine the causes of death and predictor variables for mortality in patients with SLE. Method: We evaluated 544 SLE patients who were monitored in the Lupus Clinic of Catholic Medical Center from January 1993 to December 1997 and checked clinical and laboratory variables which represent organ involvement in SLE and its disease activity. Determination of the causes of death were based on detailed clinical records in 38 cases who died during admission, and clinical and laboratory variables were compared between the survivors(n=506) and deceased(n=38). Result: Causes of death were as follows; 13 from infection(34.2%), 7 SLE-related deaths(18.4%), 6 from pulmonary hypertension(15.7%), 5 from thrombotic thrombocytopenic purpura or disseminated intravascular coagulation(13.2%), 4 from cerebrovascular accident(10.5%), and 3 from other causes(Table 2). In multivariate analysis, renal involvement(relative risk, RR 3.4), CNS involvement(RR 2.9), thrombocytopenia(RR 2.3) and age>50 years(RR 2.5) at presentation were predictor variables for mortality. Conclusion: The most common cause of death in patients with SLE was infection, followed by SLE-related death. Renal involvement, CNS involvement, thrombocytopenia, and age>50 at presentations increased the risk of death in patients with SLE.