We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K<sup>+</sup> (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-...
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https://www.riss.kr/link?id=A105380116
2017
-
518
SCIE,SCOPUS,KCI등재
학술저널
225-232(8쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K<sup>+</sup> (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-...
We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K<sup>+</sup> (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent IC<sub>50</sub> value of 2.86±0.52 µM and a Hill coefficient of 0.77±0.1. Although application of nortriptyline did not change the activation curve, nortriptyline shifted the inactivation current toward a more negative potential. Application of train pulses (1 or 2 Hz) did not change the nortriptyline-induced Kv channel inhibition, suggesting that the effects of nortiprtyline were not use-dependent. Preincubation with the Kv1.5 and Kv2.1/2.2 inhibitors, DPO-1 and guangxitoxin did not affect nortriptyline inhibition of Kv channels. From these results, we concluded that nortriptyline inhibited Kv channels in a concentration-dependent and state-independent manner independently of serotonin reuptake.
The oncogenic effects of p53-inducible gene 3 (PIG3) in colon cancer cells