Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential

다국어 초록 (Multilingual Abstract)

The high incidence of obesity has increased theneed to discover new therapeutic targets to combat obesityand obesity-related metabolic diseases. Obesity is defi ned asan abnormal accumulation of adipose tissue, which is one ofthe major metabolic organs that regulate energy homeostasis.
However, there are currently no approved anti-obesitytherapeutics that directly target adipose tissue metabolism.
With recent advances in the understanding of adipose tissuebiology, molecular mechanisms involved in brown adiposetissue expansion and metabolic activation have been investigatedas potential therapeutic targets to increase energyexpenditure. This review focuses on G-protein coupledreceptors (GPCRs) as they are the most successful class ofdruggable targets in human diseases and have an importantrole in regulating adipose tissue metabolism. We summarizerecent fi ndings on the major GPCR classes that regulatethermogenesis and mitochondrial metabolism in adipose tissue.
Improved understanding of GPCR signaling pathwaysthat regulate these processes could facilitate the developmentof novel pharmacological approaches to treat obesityand related metabolic disorders.

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