흰쥐 해마에서 수영운동이 c-fos, c-jun 발현에 미치는 영향

국문 초록 (Abstract)

본 연구는 흰쥐 해마에서 c-fos, c-jun 발현에 수영운동이 미치는 영향을 규명하는 것이다. 실험 대상은 생후 4주 흰쥐(4-weeks aged rat)와 생후 4개월 흰쥐(16-weeks aged rat)를 사용하였다. 두 집단 모두 대조군, 실험군으로 분류하였으며, 수영 운동은 1일 1시간 하였으며 1, 3, 7일 실시한 후 다음과 같은 결과를 얻을 수 있었다.
c-fos, c-jun 단백질 발현에 있어서 두 실험군 모두 운동 1, 3, 7일에서 유의하게 증가하였으며, 7일이 가장 많이 증가하였고 3일, 1일 순으로 증가 하였다. 두 실험군을 비교했을 때 생후 4주 그룹이 4개월 그룹보다 더 많은 c-fos, c-jun 단백질 발현을 보여 통계적으로 유의하게 나타났다.
따라서 수영 운동이 해마에서 c-fos, c-jun 단백질 발현을 증가시키는 것으로 나타나 운동의 효과가 있는 것으로 보이며, 수영 운동에 의한 초기발현 유전자의 활성화로 인하여 학습 및 기억과 같은 인식기능을 예방 및 개선시키며 신경성장 및 회복에 긍정적인 효과가 있는 것으로 보인다.

다국어 초록 (Multilingual Abstract)

This study is to examine the effect of swimming exercise on the expression of c-fos, c-jun protein in rat hippocampus. 4-weeks aged rats and 16-weeks aged rats were used in experimental materials. All of two groups were classified into control and swimming exercise group. Swimming exercise was practiced for an hour a day. The results were got as follows after practical application in 1 day, 3days, 7 days. The expression of c-fos, c-jun protein was increased in all of the two experimental groups significantly in 1 day, 3days, 7 days. It was increased gradually in order of after 1 day, 3days, 7 days. There seems to be the effect of swimming exercise increasing the expression of c-fos, c-jun protein in hippocampus. Therefore swimming exercise can improve cognitive function such as learning and memory and prevent through activating immediate - early gene by swimming exercise. And it seems to have the positive effect on growth and recovery of nerve.

목차 (Table of Contents)

• 요약
• Abstract
• Ⅰ. 서론
• Ⅱ. 연구방법
• Ⅲ. 결과
• Ⅳ. 논의
• Ⅴ. 결론
• 참고문헌
• 저자소개

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