We have found that readily available N‐alkyl hydroxylamines are effective reagents for the amination of organoboronic acids in the presence of trichloroacetonitrile. This amination reaction proceeds rapidly at room temperature and in the absence of ...
We have found that readily available N‐alkyl hydroxylamines are effective reagents for the amination of organoboronic acids in the presence of trichloroacetonitrile. This amination reaction proceeds rapidly at room temperature and in the absence of added metal or base, it tolerates a remarkable range of functional groups, and it can be used in the late‐stage assembly of two complex units.
The amination of organoboronic acids was achieved through the use of N‐alkyl hydroxylamines in the presence of trichloroacetonitrile but in the absence of added metal or base. This reaction features a remarkably broad substrate scope and can be applied to the late‐stage coupling of two complex units.