Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice

다국어 초록 (Multilingual Abstract)

Glucocorticoid-induced TNF receptor (GITR) was a new member of the TNF/nerve growth factor re-ceptor (TNFR/ NGFR) family and induced in murine T cels by dexamathasone. Recombinant soluble GITR (sGITR) induced an inflammation in peri-i.p. injection of 3 mg/kg in C57BL/6 mice. Spleen was enlarged and percentage of neutrophils and mon-ocytes were increased. The area of red pulp in splen was increased, while that of white pulp was decreased after GITR injection. The thickening of membrane and neutrophil infiltration was observed in peritoneal membrane with increased myelo-peroxidase activity. At later time, neutrophil in-filtration moved to inside the tisue with tisue damage. GITR ligand and GITR were expresed constitutively on the surface of splen cels and cels from peritoneal fluid. In contrast, no signi-ficant change in the spleen and in peritoneal membrane was observed in mice treated with LPS. GITR may play a role in body's inflamatory processes.