‘한국인 유전성유방암의 진료현황’에 대한 설문조사결과 = Surgeons’ Practice Patterns for Management of Hereditary Breast Cancer in Korea

다국어 초록 (Multilingual Abstract)

Purpose: The aim of this study is to examine surgeons’ practice patterns for management of hereditary breast cancer in Korea.
Methods: The structured questionnaire was circulated to the members of Korean Breast Cancer Society through e-mail between July 6 and August 14 in 2007 and 43 surgeons from 42 hospitals responded in the survey.
Results: An 81.4% of respondents (n=35) has been asking the information related to family histories of cancer and a 58.1% of respondents (n=25) has been recommending genetic testing to their patients. The indications for genetic testing of 25 surgeons who have been recommending genetic testing were as follows: breast cancer patients with family histories of breast or ovarian cancer (96%); bilateral breast cancer (80%); early-onset (64%) or male breast cancer (52%); and double primary with breast and ovarian cancer (36%). A 52% of respondents (13/25) have been doing genetic counseling before genetic testing and the genetic counseling was given by the surgeons (81.3%, 13/16) or genetic counselors (18.7%, 3/16). Although 154 BRCA1/2 mutation carriers of 95 families were identified so far, only 12 family members were managed for prophylaxis: tamoxifen chemoprevention (n=2); contralateral prophylactic mastectomy (n=2); prophylactic oophorectomy (n=8). There was no report of bilateral prophylactic mastectomy.
Conclusion: Although BRCA1/2 mutation carriers for high risk patients with hereditary breast cancer have been identifying in Korea, the practices and managements for cancer prevention seems not to perform actively. The Korean Hereditary Breast Cancer (KOHBRA) Study will serve in establishing the Korean guidelines of evidence-based clinical practice for Hereditary Breast Cancer.

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