장기적 체중감소 후 유지 = Long-term Weight Loss Maintenance

다국어 초록 (Multilingual Abstract)

It is not easy to maintain long-term weight loss even though it is the ultimate goal of obesity management. The Look AHEAD study in which 50% of participants in the intervention arm maintained a weight loss at least 5% below their initial weight after 8 years of intensive lifestyle intervention confirms a crucial role of continuous and constant application of lifestyle changes. Alteration of appetite-related hormones, energy homeostasis, nutrient metabolism, and subjective appetite are involved in biological pathways responsible for balance between energy utilization and storage following weight loss. Previous studies have shown that some appetite-related hormones and metabolites are potential predictors of weight-regain after weight loss, and specific diet pattern and physical activity could oppose weight loss regain.

국문 초록 (Abstract)

비만치료에서 체중감소 후 감소된 체중을 장기간 유지하는 것은 비만치료의 궁극적 목표이지만 이를 달성하기는 결코 쉽지 않다. 적극적 생활습관개선을 8년간 지속한 Look AHEAD 연구에서는 대상자의 약 반수에서 초기체중의 5% 이상 감량한 결과를 보여 체중감소를 유지하기 위해서는 지속적이고 일관성 있는 행동변화의 중요성을 확인해 주었다. 체중이 줄면 에너지 사용과 축적의 균형을 조정하기 위한 식욕조절 호르몬, 에너지 항상성, 영양소 대사, 주관적 식욕 변화와 같은 생물학적 경로가 관여한다. 체중 재증가를 예측하는 인자에 대한 탐색적 연구들은 일부 식욕 관여 호르몬과 대사체가 체중 재증가를 예측할 수 있고 특정한 식사 양상과 신체활동이 체중 재증가를 억제할 수 있음을 시사하였다.

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