샌달우드 오일의 항산화 및 항염증에 관한 효과 = The Effect of Anti-oxidative and Anti-inflammatory Functional in SanDalWood oil

국문 초록 (Abstract)

SDWD의 항산화작용을 실험적으로 입증하고자 ICR계 생쥐에 AAPH를 복강에 주입하여 실험적 급성산화증을 유발시킨 후 AA와 SDWD를 투여한 후 혈액성분의 변화를 측정하여 다음과 같은 결론을 얻었다.
1. 백혈구수는 모든 SDWD군에서 대조군에 비하여 현저한 감소를 보였고, 혈소판수도 SDWD군에서 대조군에 비하여 유의하게 감소하였다.
2. Albumin과 uric acid는 모든 SDWD군에서 대조군에 비하여 유의하게 증가하였고, total billirubin은 20% SDWD군에서 대조군에 비하여 유의하게 증가하였다.
3. LDL cholesterol, BUN, glucose, TG는 모든 SDWD군에서 대조군에 비하여 유의하게 감소하였고, triglyceride는 모든 SDWD군에서 대조군에 비하여 유의하게 증가하였다.
4. 혈장내 cytokine 생산중 IL-1β는 20% SDWD군에서 대조군에 비하여 유의하게 감소하였고, IFN-γ는 모든 SDWD군에서 대조군에 비하여 유의하게 증가하였다.

다국어 초록 (Multilingual Abstract)

The purpose of this study is to investigate the anti-oxidant activities and anti-inflammatory activities of SanDalWood oil by experimental methods. We caused the acute oxidant symptom by the injection of AAPH into the mouses's abdominal cavity, and then applied the aroma SDWD oil inhalation, and finally, we measured the change of blood ingredient and the resistance against the activated oxygen of the red blood cell membrane.
1. The number of white blood cell and red blood cell was remarkably decreased in all handling groups of SDWD oil comparing with the control group and the number of red blood cell was meaningfully decreased in the 10% - handling group of SDWD oil comparing with the contrast group, and the pletelet did not showed the meaningful change.
2. The Albumin and the uric acid were meaningfully increased in all handling groups of SDWD oil as against the contrast group and the total billirubin did not showed the meaningful change.
3. Glucose, LDL cholesterol, BUN, and triglyceride (TG) were meaningfully decreased in all handling groups of SDWD oil in comparison with the contrast group and the total cholesterol did not showed the meaningful change.
4. IL-1β and IFN-γ among producing the cytokine inside the plasma was meaningfully dwindled in the 20% - handling group of SDWD oil comparing with the contrast group.

참고문헌 (Reference)

1 Biurret G., 21 : 840-845, 1942

2 조수열, "고콜레스테롤 흰쥐의 간조직 항산화효소계에 미치는 민들레잎 추출물의 영향" 한국식품영양과학회 32 (32): 458-463, 2003

3 F. Javier Nieto, "Uric acid and serum antioxidant capacity: a reaction to atherosclerosis" 148 : 131-139, 2000

4 Ganesh Chandra Jagetia, "The Evaluation of Nitric Oxide Scavenging Activity of Certain Indian Medicinal Plants In Vitro: A Preliminary Study" 한국식품영양과학회 7 (7): 343-348, 2004

5 "Shinji Harakawa, Noboru Inoue, Takuya Hori, Koji Tochio, Tatsuya Kariya, Kunihito Takahashi"

6 Scartezzini P, "Review on some plants of Indian traditional medicine with antioxidant activity" 71 (71): 23-43, 2000

7 Indrajit Sinhaa, "Reduction of urinary thiols in nephrotic syndrome—a possible effect of free iron" 355 (355): 91-96, 2005

8 J. Fuchs, "Redox- modulated pathways in inflammatory skin diseases" 30 (30): 337-353, 2001

9 Bruce S. Kristala, "Oxidant-Mediated Repression of Mitochondrial Transcription in Diabetic Rats" 5 : 813-822, 1997

10 Maeda, H., "Nitric oxide and oxygen radicals in infection, inflammation, and cancer" 63 (63): 854-865, 1998

11 Banerjee S, "Modulatory influence of sandalwood oil on mouse hepatic glutathione S-transferase activity and acid soluble sulphydryl level" 68 (68): 105-109, 1993

12 Hiro-Omi Mowri, "Glucose enhancement of LDL oxidation is strictly metal ion dependent" 29 : 814-824, 2000

13 Valko M., "Free radicals and antioxidants in normal physiological functions and human disease" 39 (39): 44-84, 2007

14 Devasagayam, T.P., "Free radicals and antioxidants in human health: current status and future prospects" 52 : 794-804, 2004

15 Harold E. Seifried, "Free Radicals: The Pros and Cons of Antioxidants. The American Society for Nutritional Sciences" 134 : 3143-3163, 2004

16 Fuyuki Doge, "Effects of a 50 Hz electric field on plasma lipid peroxide level and antioxidant activity in rats" 26 : 589-594, 2005

17 Leshchinsky, T. V., "Divergence of the inflammatory response in two types of chickens" 25 : 629-638, 2001

18 KIRSCHBAUM Barry, "Correlation studies of plasma paraoxonase activity and uric acid concentration with AAPH-induced erythrocyte hemolysis in hemodialysis patients" 28 (28): 259-264, 2004

19 Hoffler U., "Comparative studies on four thrombocyte counting methods: counting in the smear preparation after Fonio, chamber counting in the phase contrast microscope, counting with the Coulter Thrombocounter, and the Technicon Auto-Counter" 12 (12): 198-206, 1974

20 Hiroshi Ihara, "Antioxidant capacities of ascorbic acid, uric acid, α-tocopherol, and bilirubin can be measured in the presence of another antioxidant, serum albumin" 18 : 45-49, 2004

21 Luo H, "Antioxidant and antimicrobial capacity of Chinese medicinal herb extracts in raw sheep meat" 70 (70): 1440-1445, 2007

22 Danniel W. W., "A foundation for analysis in the health science" 136-146, 1983