Replacement of dietary high-fat with krill or coconut oil attenuates lipid accumulation in the blood and white adipose tissue

다국어 초록 (Multilingual Abstract)

Polyunsaturated fatty acids (PUFAs) are essential FAs in the eicosanoid pathway producing signaling molecules. Due to the increased consumption of saturated FAs and their potential harmfulness, people tried to find an alternative source of FAs. This study was to investigate the replacement-effects of dietary FAs with either krill oil (n-3 PUFA) or coconut oil (MCFA) on lipid metabolism. Male rats were fed either high-fat diet (HFD), HFD+KO or HFD+CO for 10 weeks ad libitum with LPS injection. Replacement of HF with KO or CO significantly attenuated serum lipids (TG and TC) levels. Moreover, cardiovascular disease (CVD) expectancy markers were decreased (i.e. atherogenic coefficient and cardiac risk factors) in KO consumed rats than HFD. HFD+KO significantly reduced the hypertrophy in epididymal fat and alleviated CLS and macrophage infiltration. The HF+KO rats were suppressed hepatic TG accumulation and showed reduced hepatic fibrosis. Supportively, lipogenic gene expressions (i.e. FAS, ACC, C/EBP-α, SREBP-1c) in the liver was attenuated in the HFD+KO than HFD. PUFAs replacement may decrease anabolic response to the macronutrients by decreasing lipogenesis.