RISS 검색 - 국내학술지논문 상세보기

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다국어 초록 (Multilingual Abstract)

Obesity induced by high-fat diet (HFD) is one of the most widespread metabolic disorders in current society. However, there has been little study regarding the effects of HFD induced obesity in the septum of animal models of cerebral ischemia. Therefore, in the present study, we investigated effects of HFD on neuronal damage and gliosis in the septum induced by transient cerebral ischemia. Body weight, blood glucose levels and serum lipid profiles levels were measured both in the normal diet (ND) and HFD-group. And, we also investigated the effects of ND and HFD on neuronal damage and gliosis in the septum after transient cerebral ischemia using immunohistochemistry. The levels of blood glucose, serum triglyceride and total cholesterol were significantly increased in the HFD-fed gerbils compared with the ND-fed gerbils, although body weight was not significantly changed after HFD feeding. In the ND-fed gerbils, ischemia-induced neuronal damage was found in the septo-hippocampal nucleus (SHN) of the septum 7 days after ischemia. In the HFD-fed gerbils, ischemia-induced neuronal damage in the SHN was much severer compared with the ND-fed gerbils 4 and 7 days after ischemia. In addition, we found that ischemia-induced glial activation including astrocytes and microglia was accelerated and exacerbated in the HFD-fed gerbils compared with that in the ND-fed gerbils. These results indicate that HFD can lead to much exacerbated effects in ischemia-induced neuronal damage/death in the septum after ischemia-reperfusion and that it may be associated with accelerated change in glial activation.