일차성 생리통의 특성 및 약물적 치료 = A comprehensive review and the pharmacologic management of primary dysmenorrhea

다국어 초록 (Multilingual Abstract)

Dysmenorrhea is the most common gynecologic condition in women during the reproductive period. Severe dysmenorrhea pain affects their social activities, sleep, and quality of life. Nevertheless, the proportion of women with dysmenorrhea do not receive adequate medical counseling or pharmacological treatments. Primary dysmenorrhea is diagnosed clinically, and the secondary causes that can cause pelvic pain should be identified. The treatment of choice for primary dysmenorrhea is non-steroidal anti-inflammatory drugs (NSAIDs). In order to maximize the therapeutic effect, it is necessary to ensure that the appropriate medication is administered in a proper way. NSAIDs can cause adverse effects, including gastrointestinal disorders. If side effects occur or are anticipated with NSAIDs, the use of hormonal contraceptives may be recommended when contraception is considered. In addition to these pharmacological treatments, heat, dietary, and behavioral therapies have been tried and reported to have some effects. However, further research is required for robust conclusions.

참고문헌 (Reference)

1 김희연, "자궁내막증의 진단과 치료" 대한의사협회 62 (62): 513-518, 2019

2 강애라, "자궁내막증의 약물요법" 대한의사협회 53 (53): 424-429, 2010

3 이지영, "부인과 질환에서 미레나의 치료효과" 대한의사협회 62 (62): 459-465, 2019

4 Latthe P, "WHO systematic review of prevalence of chronic pelvic pain : a neglected reproductive health morbidity" 6 : 177-, 2006

5 Budoff PW, "Use of mefenamic acid in the treatment of primary dysmenorrhea" 241 : 2713-2716, 1979

6 Campbell MA, "Use of medication by adolescents for the management of menstrual discomfort" 151 : 905-913, 1997

7 Moya RA, "Transdermal glyceryl trinitrate in the management of primary dysmenorrhea" 69 : 113-118, 2000

8 Metheny WP, "The relationship among exercise, stress, and primary dysmenorrhea" 12 : 569-586, 1989

9 Norman RJ, "The potential danger of COX-2 inhibitors" 81 : 493-494, 2004

10 Oh ST, "The management of chronic pelvic pain" 51 : 53-64, 2008

11 Yucel N, "The levonorgestrel-releasing intrauterine system is associated with a reduction in dysmenorrhoea and dyspareunia, a decre-ase in CA 125 levels, and an increase in quality of life in women with suspected endometriosis" 58 : 560-563, 2018

12 Ensiyeh Jenabi, "The effect of bee prepolis on primary dysmenorrhea: a randomized clinical trial" 대한산부인과학회 62 (62): 352-356, 2019

13 Roumen FJ, "The contraceptive vaginal ring compared with the combined oral contraceptive pill : a comprehensive review of randomized controlled trials" 75 : 420-429, 2007

14 Anderson FD, "Safety and efficacy of an extended-regimen oral contraceptive utilizing continuous low-dose ethinyl estradiol" 73 : 229-234, 2006

15 Chan WY, "Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen : effect on prostaglandin levels in menstrual fluid" 135 : 102-108, 1979

16 Ling FW, "Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis" 93 : 51-58, 1999

17 Altunyurt S, "Primary dysmenorrhea and uterine blood flow : a color Doppler study" 50 : 251-255, 2005

18 Dawood MY, "Primary dysmenorrhea : advances in pathoge-nesis and management" 108 : 428-441, 2006

19 Golomb LM, "Primary dysmenor-rhea and physical activity" 30 : 906-909, 1998

20 Burnett MA, "Prevalence of primary dysmenorrhea in Canada" 27 : 765-770, 2005

21 Davis AR, "Oral contraceptives for dysmenorrhea in adolescent girls : a randomized trial" 106 : 97-104, 2005

22 Wong CL, "Oral contracep-tive pill as treatment for primary dysmenorrhoea" (2) : CD002120-, 2009

23 Marjoribanks J, "Nonsteroidal anti-inflammatory drugs for primary dysmenorrhoea" (4) : CD001751-, 2003

24 Ylikorkala O, "New concepts in dysmenorrhea" 130 : 833-847, 1978

25 Buhimschi I, "Involve-ment of a nitric oxide-cyclic guanosine monophosphate pathway in control of human uterine contractility during pregnancy" 172 : 1577-1584, 1995

26 Nigam S, "Increased concentrations of eicosanoids and platelet-activating factor in menstrual blood from women with primary dysmenorrhea" 4 : 137-141, 1991

27 Baker FC, "High nocturnal body temperatures and disturbed sleep in women with primary dysmenorrhea" 277 : E1013-E1021, 1999

28 Wilson ML, "Herbal and dietary therapies for pri-mary and secondary dysmenorrhoea" 97 : 44-, 2001

29 Latthe P, "Factors predis-posing women to chronic pelvic pain : systematic review" 332 : 749-755, 2006

30 Sundell G, "Factors influencing the prevalence and severity of dysmenorrhoea in young women" 97 : 588-594, 1990

31 Klein JR, "Epidemiology of adolescent dysmenorrhea" 68 : 661-664, 1981

32 Zahradnik HP, "Efficacy and safety of the new antiandrogenic oral contraceptive Belara" 57 : 103-109, 1998

33 Athanasiou S, "Effects of indomethacin on follicular structure, vascularity, and func-tion over the periovulatory period in women" 65 : 556-560, 1996

34 Lee EH, "Dysmenorrhea and menstrual attitudes in adult women" 9 : 105-112, 2003

35 Morrow C, "Dysmenorrhea" 36 : 19-32, 2009

36 French L, "Dysmenorrhea" 71 : 285-291, 2005

37 Harel Z, "Depo-Provera in adolescents : effects of early second injection or prior oral contraception" 16 : 379-384, 1995

38 Smith RP, "Cyclic pelvic pain and dysmenorrhea" 20 : 753-764, 1993

39 Pittrof R, "Crossover study of glyceryl trinitrate patches for con-trolling pain in women with severe dysmenorrhoea" 312 : 884-, 1996

40 Akin M, "Continuous, low-level, topical heat wrap therapy as com-pared to acetaminophen for primary dysmenorrhea" 49 : 739-745, 2004

41 Akin MD, "Continuous low-level topical heat in the treatment of dysmenorrhea" 97 : 343-349, 2001

42 Hamideh Pakniat, "Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea: a single-blind clinical trial" 대한산부인과학회 62 (62): 462-468, 2019

43 Proctor ML, "Combined oral contra-ceptive pill(OCP)as treatment for primary dysmenorrhoea" (4) : CD002120-, 2001

44 Croxatto HB, "Clinical profile of Implanon : a single-rod etono-gestrel contraceptive implant" 5 (5): 21-28, 2000

45 Zhu X, "Chinese herbal medicine for primary dysmenorrhoea" (2) : CD005288-, 2008

46 Proctor ML, "Behavioural interventions for primary and secondary dysmenorrhoea" (3) : CD002248-, 2007