본 연구의 목적은 DSS로 유발시킨 대장염 동물모델에서 생식섭취가 장관 내 면역조절에 미치는 영향에 대하여 검토해보고자 했다. 그 결과, 생식섭취가 DSS로 유발시킨 대장염에서 normal군보...
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https://www.riss.kr/link?id=A76297578
2007
Korean
KCI등재,SCOPUS
학술저널
32-42(11쪽)
8
0
상세조회0
다운로드국문 초록 (Abstract)
본 연구의 목적은 DSS로 유발시킨 대장염 동물모델에서 생식섭취가 장관 내 면역조절에 미치는 영향에 대하여 검토해보고자 했다. 그 결과, 생식섭취가 DSS로 유발시킨 대장염에서 normal군보...
본 연구의 목적은 DSS로 유발시킨 대장염 동물모델에서 생식섭취가 장관 내 면역조절에 미치는 영향에 대하여 검토해보고자 했다. 그 결과, 생식섭취가 DSS로 유발시킨 대장염에서 normal군보다 IFN-γ의 함량을 증가시키고, IL-4와 IL-10의 함량은 감소시킴이 관찰되었다. 또한, 증가된 Th1 세포의 cytokine과 감소된 Th2 세포의 cytokine은 염증이 유발된 후, 생식을 통한 치료로써 변환시킬 수 있음을 증명하였다. 이러한 연구 결과를 볼 때 DSS로 유발시킨 대장염에서 생식섭취를 통한 치료는 IL-4와 IL-10과 같은 염증성 cytokine의 억제기능을 통하여 면역시스템을 강화시키고, 손상된 염증을 완화시켜 줄 것으로 판단된다. 생식의 면역조절에 관한 자세한 기전은 아직 밝혀져 있지 않지만, 염증성장질환에서 생식섭취가 면역학적 역할에 대한 새로운 양상들에 대한 연구가 더욱더 필요할 것으로 사료된다.
다국어 초록 (Multilingual Abstract)
This study was conducted on the immunoregulatory effect of Saengshik on gut-associated lymphoid tissue with inflammatory bowel disease. Although the contents of IgA increased in mesenteric lymph node, IgE con-tent was suppressed by Saengshik. The same...
This study was conducted on the immunoregulatory effect of Saengshik on gut-associated lymphoid tissue with inflammatory bowel disease. Although the contents of IgA increased in mesenteric lymph node, IgE con-tent was suppressed by Saengshik. The same results were found in spleen, but IgA and IgE responses were very weak. Concentration of fecal IgA was high from the first day through the third day in Saengshik group. In DSS+Saengshik group, concentration of IgA was high till the 2nd day and it maintained the highest level among the test groups on the 5th day. Concentration of IFN-gamma and IL-2 was the highest in the Saengshik group, but the concentration of TNF-alpha was lower in DSS+Saengshik compared to DSS. The expressions of STAT1 in Saengshik group were high, while those of STAT6 were low. According to these findings, Saengshik exhibited effectiveness via increasing the IgA production, suppressing the IgE production, followed by inhibiting the production of IL-4 and IL-10. Saengshik also strengthened the immune system and alleviated injury in DSS-induced inflammation.
참고문헌 (Reference)
1 송미경, "생식 섭취가 지방간 개선 및 지질 대사에 미치는 영향" 한국영양학회 36 (36): 834-840, 2003
2 강상모, "고지혈증 유발 흰쥐에 있어서 생식의 건강개선효과" 한국식품영양과학회 32 (32): 906-912, 2003
3 Stephen AM, "Water-holding by dietary fibre in vitro and its relationship to faecal output in man" 20 : 722-729, 1979
4 Leo S, "Ulcerative colitis in remession is it possible to predict the risk of relapse?" 44 : 217-221, 1989
5 McGhee JR, "The mucosal immune system. In Fiundamental Immunology. 4th ed" Lippincott-Raven Publishers 1999
6 Kiyono H, "The mucosal immune system : features of inductive and effector sites to consider in mucosal immunization and vaccine development" 4 : 54-62, 1992
7 Lin CC, "The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin" 24 : 31-36, 1996
8 Imada K, "The Jak-STAT pathway" 37 : 1-11, 2000
9 Tappenden KA, "Short chain fatty fatty acid (SCFA) supplementation of total parenteral nutrition (TPN) improves whole body response to intestinal resection" 9 : 862A-, 1995
10 Fukushima C, "Salivary IgA and oral candidiasis in asthmatic patients treated with inhaled corticosteroid" 42 : 601-604, 2005
1 송미경, "생식 섭취가 지방간 개선 및 지질 대사에 미치는 영향" 한국영양학회 36 (36): 834-840, 2003
2 강상모, "고지혈증 유발 흰쥐에 있어서 생식의 건강개선효과" 한국식품영양과학회 32 (32): 906-912, 2003
3 Stephen AM, "Water-holding by dietary fibre in vitro and its relationship to faecal output in man" 20 : 722-729, 1979
4 Leo S, "Ulcerative colitis in remession is it possible to predict the risk of relapse?" 44 : 217-221, 1989
5 McGhee JR, "The mucosal immune system. In Fiundamental Immunology. 4th ed" Lippincott-Raven Publishers 1999
6 Kiyono H, "The mucosal immune system : features of inductive and effector sites to consider in mucosal immunization and vaccine development" 4 : 54-62, 1992
7 Lin CC, "The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin" 24 : 31-36, 1996
8 Imada K, "The Jak-STAT pathway" 37 : 1-11, 2000
9 Tappenden KA, "Short chain fatty fatty acid (SCFA) supplementation of total parenteral nutrition (TPN) improves whole body response to intestinal resection" 9 : 862A-, 1995
10 Fukushima C, "Salivary IgA and oral candidiasis in asthmatic patients treated with inhaled corticosteroid" 42 : 601-604, 2005
11 Bromberg J, "STAT proteins : signal tranducers and activators of transcription" 333 : 138-151, 2001
12 American Institute of Nutrition, "Report of the American Institute of Nutrition ad hoc Committee on Standards for Nutrition Studies" 107 : 1340-1348, 1977
13 Blumberg RS, "Relapse of chronic inflammatory bowel disease" 98 : 792-796, 1990
14 Kojouharoff G, "Neutralization of tumor necrosis factor(TNF)but not of IL-1 reduce inflammation in chronic dextran sulfate sodium-induced colitis in mice" 107 : 353-358, 1997
15 Connel AM, "Natural fiber and bowel dysfunction" 29 : 1427-1431, 1976
16 Duncan DB, "Multiple range and multiple F test" 11 : 1-42, 1955
17 Stephen AM, "Mechanism od action of dietary fibre in the human colon" 284 : 283-284, 1980
18 Sugano M, "Lipid-lowering activity of phytostanols in rats" 24 : 301-309, 1976
19 Hallert C, "Ispaghula husk may relieve gastrointestinal symptoms in ulcerative colitis in remission" 26 : 747-750, 1991
20 Kwon KH, "Interleukin-1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis" 337 : 647-654, 2005
21 Seder RA, "Interleukin- 12 acts directly on CD4+ T cells to enhance priming for interferon γ production and diminishes interleukin-4 inhibition of such priming" 90 : 10188-10192, 1993
22 Obermeier F, "Interferon-gamma(IFN-γ)and tumor necrosis factor(TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulfate sodium(DSS)-induced colitis in mice" 116 : 238-245, 1999
23 Schreiber S, "Immunoregulatory role of interleukin 10 in patient with inflammatory bowel disease" 108 : 1434-1444, 1995
24 Moutoussamy S, "Growth-hormone-receptor and cytokine-receptor-family signaling" 255 : 1-11, 1998
25 Lim BO, "Free bile acids inhibit IgE production by mouse spleen lymphocytes stimulated by lipopolysaccharide and interleukins" 59 : 624-627, 1995
26 Metcalfe DD, "Food allergy" 3 : 881-886, 1991
27 Sandberg AS, "Experimental model for in vivo determination of dietary fibre and its effect on the absorption of nutrients in the small intestine" 45 : 283-294, 1981
28 Suk K, "Essential role of caspase-11 in activation-induced cell death of rat astrocytes" 80 : 230-238, 2002
29 Shoda R, "Epidemiologic analysis of Crohn's disease in Japan; increased dietary intake of n-6 poluunsaturated fatty acids and animal protein relates to the increased incidence of Crohn's disease in Japan" 63 : 741-745, 1996
30 Rao AV., "Effects of dietary fiber on intestinal microflora and health, In Dietary fiber in Health & Disease" Egan Press 257-266, 1995
31 Finegold SM, "Effects of diet on human fecal flora : comparison of Japanese and American diets" 27 : 1456-1469, 1974
32 Yamada K, "Effect of unsaturated fatty acids and antioxidants on immunoglobulin production of rat mesenteric lymphnode lymphocytes of sprague-dawley rats" 120 : 138-144, 1996
33 Hung P, "Effect of unsaturated fatty acids and alpha-tocopherol on immunoglobulin levels in culture medium of rat mesenteric lymph node and spleen lymphocytes" 121 : 1054-1060, 1997
34 Lim BO, "Effect of ganhuangenin obtained from Scutellaria radix on the chemical mediator production of peritoneal exudate cells and immunoglobulin E level of mesenteric lymhp node lymphocytes in sprague-dawley rats" 16 : 166-170, 2001
35 Lim BO, "Effect of dietary level of pectin on immunoglobulin and cytokine production by mesenteric lymph node lymphocytes and interleukin-2 receptor in rats" 8 : 14-16, 2002
36 Burkitt DP, "Effect of dietary fiber on stools and transit-times, and its role in the causation of disease" 300 : 1408-1412, 1972
37 Lim BO, "Ditary fibers modulate indices of intestinal immune function in rats" 127 : 663-667, 1997
38 Lim BO, "Dietary(n-6)and(n-3)fatty acids and energy restirction modulate mesenteric lymph node lymphocytes function in autoimmune-prone(NZBxNZW)F1 mice" 130 : 1657-1664, 2000
39 Cranston D, "Dietary fibre and gastrointestinal disease" 75 : 508-512, 1988
40 Cummings JH, "Change in fecal composition and colonic function due to cereal fiber" 29 : 1468-1473, 1976
41 Neurath MF, "Antibodies to interleukin 12 abrogate established experimental colitis in mice" 182 : 1281-1290, 1995
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | ![]() |
2014-06-24 | 학회명변경 | 한글명 : 한국식품영양과학회지 -> 한국식품영양과학회영문명 : Journal of the Korean Society of Food Science and Nutrition -> The Korean Society of Food Science and Nutrition | ![]() |
2014-04-02 | 학회명변경 | 한글명 : 한국식품영양과학회 -> 한국식품영양과학회지영문명 : 미등록 -> Journal of the Korean Society of Food Science and Nutrition | ![]() |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2005-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2002-07-01 | 평가 | 등재학술지 선정 (등재후보2차) | ![]() |
2000-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 1.03 | 1.03 | 1.13 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
1.18 | 1.2 | 1.993 | 0.21 |