조현병 환자와 발병하지 않은 일차친족에서 인지조절 결함의 비교 = Comparison of Cognitive Control Deficits in Patients with Schizophrenia and Their Unaffected First-Degree Relatives

다국어 초록 (Multilingual Abstract)

Objectives This study aimed to identify the differences in the profiles of cognitive control deficits among schizophrenic patients and endophenotypes.
Methods The study examined three groups: remitted patients with schizophrenia (n=54), unaffected first-degree relatives of the probands with schizophrenia (n=36), and a healthy control group (n=51), which were all matched for age, sex, and years of education. The AX version of the continuous performance test was used to examine cognitive control. The error rate, correct response times of each subset (AX, BX, AY, BY), and d’ as an indication of the accuracy sensitivity index were calculated. The psychopathology, intelligence, and psychomotor speed were also assessed.
Results Patients with schizophrenia showed significantly poorer error rates and d’ in the AX and BX subsets than the others. They showed more delayed correct response times than the healthy control group in all subsets. The first-degree relatives also showed more delayed correct response times in the BX and AY subsets than the healthy control group, but were similar to the patients.
Conclusion These findings suggest that cognitive control is impaired in schizophrenia and endophynotypes possibly share this delayed information processing from the higher loading states of cognitive control.

참고문헌 (Reference)

1 안용민, "한글판 Montgomery-Åsberg 우울증 평가 척도의 표준화 연구" 대한신경정신의학회 44 (44): 466-476, 2005

2 김도훈, "조현병 환자와 발병하지 않은 일차친족에서 신경인지의 결함" 대한생물정신의학회 21 (21): 65-73, 2014

3 Lee YS, "Validity of short forms of the Korean-Wechsler Adult Intelligence Scale" 14 : 111-116, 1995

4 Buschman TJ, "Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices" 315 : 1860-1862, 2007

5 Rotaru DC, "The role of glutamatergic inputs onto parvalbumin-positive interneurons: relevance for schizophrenia" 23 : 97-109, 2012

6 Miller EK, "The prefrontal cortex and cognitive control" 1 : 59-65, 2000

7 김도훈, "Shared and Distinct Neurocognitive Endophenotypes of Schizophrenia and Psychotic Bipolar Disorder" 대한정신약물학회 13 (13): 94-102, 2015

8 Servan-Schreiber D, "Schizophrenic deficits in the processing of context. A test of a theoretical model" 53 : 1105-1112, 1996

9 Morrison MW, "Reliability of the Finger Tapping Test and a note on sex differences" 48 : 139-142, 1979

10 Egan MF, "Relative risk for cognitive impairments in siblings of patients with schizophrenia" 50 : 98-107, 2001

11 Wang Q, "Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: a study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls" 89 : 293-298, 2007

12 Richard AE, "Persistence, diagnostic specificity and genetic liability for context-processing deficits in schizophrenia" 147 : 75-80, 2013

13 Barker MJ, "Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: a meta-analysis" 19 : 437-454, 2004

14 Cannon TD, "Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers" 51 : 651-661, 1994

15 Minzenberg MJ, "Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia" 66 : 811-822, 2009

16 Green MF, "Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS" 72 : 41-51, 2004

17 Docherty NM, "Immediate memory, attention and communication disturbances in schizophrenia patients and their relatives" 29 : 189-197, 1999

18 Chkonia E, "First-order relatives of schizophrenic patients are not impaired in the Continuous Performance Test" 32 : 481-486, 2010

19 Cohen RM, "Dysfunction in a prefrontal substrate of sustained attention in schizophrenia" 40 : 2031-2039, 1987

20 Barch DM, "Dissociating working memory from task difficulty in human prefrontal cortex" 35 : 1373-1380, 1997

21 American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders" American Psychiatric Association 1994

22 Hahn OS, "Development of Korean version of Structured Clinical Interview Schedule for DSM-IV Axis I Disorder: interrater reliability" 39 : 362-372, 2000

23 Cohen JD, "Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasks" 108 : 120-133, 1999

24 Martínez-Arán A, "Cognitive dysfunctions in bipolar disorder: evidence of neuropsychological disturbances" 69 : 2-18, 2000

25 Snitz BE, "Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes" 32 : 179-194, 2006

26 Sitskoorn MM, "Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis" 71 : 285-295, 2004

27 Ophir E, "Cognitive control in media multitaskers" 106 : 15583-15587, 2009

28 Leucht S, "Clinical implications of Brief Psychiatric Rating Scale scores" 187 : 366-371, 2005

29 Braver TS, "A theory of cognitive control, aging cognition, and neuromodulation" 26 : 809-817, 2002

30 MacDonald AW 3rd, "A specific deficit in context processing in the unaffected siblings of patients with schizophrenia" 60 : 57-65, 2003

31 Cohen JD, "A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges" 351 : 1515-1527, 1996