대전.충남 지역 여성 유방암 발생과 사망 추이

다국어 초록 (Multilingual Abstract)

This study analyzed the changes in the incidence of female breast cancer, which had been on the constant increase for more than ten years in South Korea, on the basis of the data from the local cancer registration in Daejeon and Chungnam Province from 2000 to 2013. The subjects were 10,816 female residing in Daejeon and Chungnam Province who had the condition developed from January 1, 2000 to December 31, 2013; comparative analysis of its crude rate, its age-standardized rate, and its yearly variation rate was made to determine the changes in the histological forms of breast cancer as well as the changes in its mortality rate. The principal results of this study are as follows:

1. The crude rate of breast cancer among 100,000 women in Daejeon and Chungnam Province was 103.3% higher in Daejeon and 217.9% higher in Chungnam Province in 2013 than in 2000. The age-standardized rate was 64.4% higher in Daejeon and 169.6% higher in Chungnam Province in 2013 than in 2000.

2. As for the average incidence rate between 2000 and 2013, the crude rate from 2010 to 2013 increased by 86.3% in Daejeon and by 103.9% in Chungnam Province, compared with the period from 2000 to 2004. The age-standardized rate increased by 53.8% in Daejeon and by 81.1% in Chungnam Province.

3. As for the average rate in each of the age groups during the fourteen-year period from 2000 to 2013, it was highest for peri-menopausal women in their forties and fifties and began to decrease drastically at the age of 60 in both Daejeon and Chungnam Province. The incidence rate was 0% for teenagers in Daejeon and was low for the age group in Chungnam Province. Contrary to the Western society where the rate increases with age, it was ≥15% for those aged <40 and was highest for those aged 45-49 in both Daejeon and Chungnam Province. The increase in the crude rate was remarkable for post-menopausal women in their fifties and sixties in the period between 2010 and 2013, compared with that between 2000 and 2004.

4. The changes in the incidence rate of cancer from 2000 to 2003 was analyzed using Joinpoint regression; its average yearly increase rate was 4.0% in Daejeon and 7.7% in Chungnam Province. The rate increased from 2000 to 2011 and began to decrease in 2011 in Daejeon, whereas it increased drastically from 2000 to 2002 and increased steadily from 2002 to 2013. Neither the increase since 2011 in Daejeon nor the drastic increase until 2002 in Chungnam Province was statistically significant.

5. According to the histological typology, invasive ductal carcinoma appeared frequently: its incidence rate was 3.2% higher in Daejon and 3.8% higher in Chungnam Province in 2013 than in 2000. Each type of cancer decreased in the incidence rate in Daejeon and the rate of invasive ductal carcinoma increased by 1.9% and the other types of cancer decreased by 6.3% in Chungnam Province.

6. The mortality rate of breast cancer among 100,000 women increased from 4.7 in 2005 to 6.6 in 2013 in Daejeon and from 4.6 in 2005 to 5.2 in 2003 in Chungnam Province. It contrasts with the decrease in the mortality rate of female cancer in general.

On the basis of these results, it was possible to review the changes in the incidence of breast cancer in Daejeon and Chungnam Province. It is necessary to review similar cases in other countries and positively run prevention, early diagnosis, and rehabilitation programs appropriate for each community.

목차 (Table of Contents)

• Ⅰ. 서 론 1
• Ⅱ. 조사대상 및 방법 3
• 1. 조사대상 및 기간 3
• 2. 조사방법 및 내용 3
• Ⅲ. 결 과 6
• 1. 여성 유방암의 발생률 변화 6
• 2. 여성 유방암의 연령표준화 발생률의 추세 13
• 3. 여성 유방암의 조직학적 형태 차이의 변화 15
• 4. 여성 유방암의 사망률 추세 19
• Ⅳ. 고 찰 21
• Ⅴ. 결 론 24
• 참고문헌 26
• ABSTRACT 30