국소마취제에 함유된 에피네피린의 함량이 골격근에 미치는 영향 = The Effect of Lidocaine Containing Various Amount of Epinephine on Skeletal Muscle in Rats＊

다국어 초록 (Multilingual Abstract)

The purpose of this study is to examine how 2% lidocaine HCl and 2% lidocaine HCl containing epinephrine in various amounts (1 : 100,000, 1 : 50,000) influence the skeletal muscle.
30 Sprague-Dawley rats were used in 3 groups in the experiment.
In injected intramuscularly 2% lidocaine HCl without epinephrine, lidocaine HCl with epinephrine 1 : 100,000 and 2% lidocaine HCl with epinephrine 1 : 50,000 on the surface of the gracilis anticus of the both thighs of them respectively.
And as the Control, I injected normal saline on the gracilis posticus of the both thighs similarly. After single injection, two rats was killed on the 1st, 2nd, 4th, 8th and 16th day and then their muscles were removed and prepared for light microscopic examination.
The obtained results are as following.
After single local injection, clinically effective concentrations of local anesthetics (lidocaine HCl, 2%) and epinephrine, alone or in combination, caused inflammation, atrophy and necrosis in skeletal muscle of rats. While saline injected as control caused no specific changes except for mild edema.
Damage was rapidly resolved and completed and muscle regeneration was followed. The initial muscular damage was most severe in 2% lidocaine HCl with epinephrine 1 : 100, 000 and in 2% lidocaine HCl with epinephrine 1 : 50,000, but the muscular regeneration was more favorable in 2% lidocaine HCl without epinephrine.
The findings suggested that the muscular damage was caused directly by local anesthetics rather than epinephrine contained in lidocaine without relation to amounts of concentration and that the vascular contraction by the action of epinephrine delayed the muscular damage.