P063 A correlation between skin cancer and vitiligo in 27,507 gastroesophageal reflux disease patients = P063 A correlation between skin cancer and vitiligo in 27,507 gastroesophageal reflux disease patients

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

Background: There can be various explanations about the relationship between vitiligo and skin cancer as regards pathogenesis of vitiligo. The autoimmunity in vitiligo can promote anti-cancer immunity so that skin cancer might be less common in vitiligo patients. On the other hand, if the destruction of melanocytes disrupts natural protection from ultraviolet radiation, the risk of skin cancer might be increased. Objectives: To investigate the relationship between vitiligo and skin cancer. Methods: We retrospectively reviewed medical records (from Jan. 2000 to Mar. 2016) of SMG-SNU Boramae Medical Center. We extracted data from 27,507 patients with gastroesophageal reflux disease, which is, in general, known to be associated with neither vitiligo nor skin cancer. The following data were obtained: demographics, the number of dermatology clinic visits, and the presence of vitiligo or skin cancer. Results: We found that the prevalence of skin cancer had a positive correlation with that of vitiligo and this correlation was persistent after control of age and sex. However, there was no correlation of vitiligo and skin cancer when ‘the number of visit’ was controlled. Conclusion: In our study, increased prevalence of skin cancer in vitiligo patients may not demonstrate true association and result from more frequent dermatologic clinic visits. Further studies are required to establish relationship between vitiligo and skin cancer.