Rosacea and Use of Continuous Positive Airway Pressure Mask for Obstructive Sleep Apnea Syndrome: Report of Five Cases = Rosacea and Use of Continuous Positive Airway Pressure Mask for Obstructive Sleep Apnea Syndrome: Report of Five Cases

다국어 초록 (Multilingual Abstract)

Rosacea is a chronic inflammatory skin disease of unknown etiology. We noticed a series of patients who were diagnosed with rosacea as well as obstructive sleep apnea syndrome (OSAS), for which they used a continuous positive airway pressure (CPAP) mask. This case series aims to give insight in the possible relationship between rosacea and the use of a CPAP mask for OSAS. We present five patients with OSAS who developed or worsened rosacea symptoms after use of a CPAP mask covering nose and mouth. Two patients showed centrofacial symptoms consistent with the shape of the CPAP mask; three patients had nasal cutaneous symptoms. It is postulated that the occlusive effect of the CPAP mask, increasing skin humidity and temperature, can induce primary symptoms in patients with an underlying sensibility for rosacea. This could have implications for choice of CPAP mask type and topical therapeutic options for rosacea. (Ann Dermatol 32(3) 247∼250, 2020)

참고문헌 (Reference)

1 Akin Belli A, "The relationship between rosacea and insulin resistance and metabolic syndrome" 26 : 260-264, 2016

2 Dahl MV, "Temperature regulates bacterial protein production : possible role in rosacea" 50 : 266-272, 2004

3 Gallo RL, "Standard classification and pathophysiology of rosacea : the 2017 update by the National Rosacea Society expert committee" 78 : 148-155, 2018

4 Two AM, "Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors" 72 : 749-758, 2015

5 Rainer BM, "Rosacea is associated with chronic systemic diseases in a skin severity-dependent manner : results of a case-control study" 73 : 604-608, 2015

6 Ozkol HU, "Rosacea and exposure to tandoor heat: is there an association?" 54 : 1429-1434, 2015

7 Duman N, "Rosacea and cardiovascular risk factors : a case control study" 28 : 1165-1169, 2014

8 Karaca Z, "Obstructive sleep apnoea syndrome is associated with relative hypocortisolemia and decreased hypothalamo-pituitary-adrenal axis response to 1 and 250μg ACTH and glucagon stimulation tests" 14 : 160-164, 2013

9 Hopps E, "Obstructive sleep apnea syndrome : links betwen pathophysiology and cardiovascular complications" 38 : E362-E370, 2015

10 Qian Y, "Obstructive sleep apnea predicts risk of metabolic syndrome independently of obesity : a meta-analysis" 12 : 1077-1087, 2016

11 Holmes AD, "Integrative concepts of rosacea pathophysiology, clinical presentation and new therapeutics" 26 : 659-667, 2017

12 Schwartz M, "Effects of CPAP and mandibular advancement device treatment in obstructive sleep apnea patients : a systematic review and meta-analysis" 22 : 555-568, 2018

13 Weiss E, "Diet and rosacea : the role of dietary change in the management of rosacea" 7 : 31-37, 2017

14 Diczig B, "Contact hypersensitivity in rosacea-a report on 143 cases" 32 : e347-e349, 2018

15 Sozer V, "Changes in inflammatory mediators as a result of intermittent hypoxia in obstructive sleep apnea syndrome" 12 : 1615-1622, 2018