만삭임신 자궁근에 잇어서 3H E1-SO4 및 3H E2-17B의 대사에 관한 연구 = Metabolism of tritiated estrone sulfate and estradiol-17B in human myomterium at term pregnancy

다국어 초록 (Multilingual Abstract)

During the menstrual cycle and during pregnancy estrone sulface is one of the major estrogens circulating in blood However the physiological sighnificance of estrone sulfate has not been well elucidated although baird et al. have suggested estrone sulfate as a possible precursor for free estrogens The interest in this problem was stimulated by studies which demonstracted that human uterine tissue contains enzyme systems, capable of metabolizing free and conjugated estrogens This study followed the metabolic fate of tritiated estrone sulfate and estradiol 17B under in vitro conditions in human myometrium obtained at term pregnancies. In addition, the tissue uptake and subcellular distribution of radiolabeled estrogens were analysed.