[P162] A case of systemic AL Amyloidosis = [P162] A case of systemic AL Amyloidosis

다국어 초록 (Multilingual Abstract)

Cutaneous amyloidosis may be classified into two categories: localized cutaneous amyloidosis in which there is no evident systemic involvement, and systemic amyloidosis. AL (Amyloidosis Light-chain) amyloidosis is the most common type of systemic amyloidosis, and occurs as a result of an underlying plasma cell dyscrasia or multiple myeloma. Its clinical manifestations are extremely variable. Periorbital ecchymoses and macroglossia are very strongly suggestive clinical features and multiple vital organ dysfunction is common. Most common adverse effects include heart complications, such as heart failure and irregular heartbeat, affecting more than one third of AL amyloidosis patients. A 79-year-old man was presented with ruptured large bulla on right lower leg and yellowish papules on anterior neck for an unknown period. He had recent history of heart failure and consulted to us for wound care. Multiple ecchymoses were found on face, especially periorbital area, and macroglossia was observed. We took a skin biopsy under the impression of systemic amyloidosis and the diagnosis was confirmed by histopathologic findings. Congo red stain revealed amyloid deposits in dermal vessels. We referred him to hematologic department to evaluate plasma cell dyscrasia including multiple myeloma. Herein, we report an interesting case of an old man who has systemic AL amyloidosis with various typical features.