Streptozotocin에 의해 유도된 당뇨 흰쥐의 고혈당과 고지혈에 미치는 오미자 추출물의 효과

다국어 초록 (Multilingual Abstract)

To investigate the antihyperglycemic and antihyperlipemic effect of 80% ethanol extract of Schizandra Chinensis fruit, we induced diabetes in the rats with streptozotocin (STZ) and administered schizandra extract or Acarbose to diabetic rats for 21 days by oral administration. Consequently, the groups treated using schizandra extract decreased blood glucose levels more 39% than no treatment group and the case of Acarbose group was decreased it about 21%. The concentration of cholesterol, triglyceride and LDL-C in blood was also decreased while treating schizandra extract, on the other hand, HDL-C concentration was significantly increased it about 26%. Those results induced that anti-atherogenic index (AAI) in blood was improved more than 82% level like normal condition, especially in treatment of schizandra extract 100 mg. The lipid profiled in feces was likewise showed apparent tendency to decrease and food efficiency ratio of diabetic rats was became higher for treatment with schizandra extract, but Acarbose group had low efficiency in compared with the result of glucose level and lipid profile in blood. As a result, schizandra extract is regard a good medicine for diabetes due to improve physical constitution, blood glucose and lipid level caused hyperglycemia and suggest that schizandra extract has real effects on the diabetes complication as atherosclerosis, coronary heart disease, high blood pressure.

목차 (Table of Contents)

• Abstract
• 1. 서론
• 2. 재료 및 방법
• 3. 결과 및 고찰
• 4. 결론
• References

참고문헌 (Reference)

1 고병섭, "오미자 추출물의 혈당 강하 효과에 관한 연구" 한국응용생명화학회 47 (47): 258-264, 2004

2 권후자, "오미자 추출물의 생리활성" 한국식품저장유통학회 15 (15): 587-592, 2008

3 김관수, "오미자 리그난 성분의 정량분석" 한국생약학회 33 (33): 272-276, 2002

4 강상모, "고지혈증 유발 흰쥐에 있어서 생식의 건강개선효과" 한국식품영양과학회 32 (32): 906-912, 2003

5 Cohen, M. P, "Treatment with acarbose, an α-glucosidase inhibitor, reduces increased albumin excretion in streptozotocin-diabetic rats" 26 : 1355-1361, 1995

6 Like, A. A, "Streptozotocin-induced pancreatic insulities: new model of diabetes mellitus" 193 : 415-417, 1976

7 최은오, "Schizandrin함량이 높은 음료개발을 위한 오미자 (Schizandra chinensis Baillon)의 추출조건" 한국생물공학회 23 (23): 271-275, 2008

8 Gray, A. M, "Natural’s own pharmacy: the diabetes perspective" 56 : 507-517, 1997

9 Brown, W. V, "Lipoprotein disorders in diabetes mellitus" 78 : 143-161, 1994

10 Caspary, W. F, "Increase of intestinal brush borderin mucosa of streptozotocin-diabetic rats" 8 : 412-414, 1972

11 Friedewald, W. T, "Estimation of the concentration of low-densitylipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge" 18 : 499-502, 1972

12 Oh, C. H, "Effects of Schizandra chinensis fructus on the immunoregulatory action and apoptosis of L1210 cells" 33 : 384-388, 2001

13 Lee, Y. A, "Effect of hovenia dulcis THUNBER var koreana nakai fruits extracts on glucose, lipid metabolism and antioxidant activities in streptozotocin induced diabetic rat" 11 : 533-538, 2005

14 Guido, S, "Effect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet" 30 : 292-294, 1992

15 Venugopal P. Menon, "Effect of Photo-Irradiated Curcumin Treatment Against Oxidative Stress in Streptozotocin-Induced Diabetic Rats" 한국식품영양과학회 8 (8): 251-255, 2005

16 Furuse, M, "Dietary sorbose prevents and improves hyperglycemia in genetically diabetic" J. Nutrition 59-65, 1993

17 Stamler, J, "Diabtes, other risk factors, and 12-yr cardiovascular mortality for men screened in the multiple risk factor intervention trial" 15 : 434-444, 1993

18 Chae, H. J, "Comparison of on rat intestinal digestive enzyme inhibitory activity and antioxidant enzyme activity of korean and chinese Schizandra chinensis" 11 : 517-523, 2005

19 고성희, "Comparison of anti-oxidant activities of seventy herbs that have been used in Korean traditional medicine" 한국영양학회 2 (2): 143-151, 2008

20 Basu, M, "Anti-atherogenic effects of seabuckthorn seed oi" 14 : 770-777, 2007

21 Akiyama, T, "Activation of Reg gene, a gene for insulin producing β-cell regeneration: Poly (ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly (ADP-ribosyl) ation" 98 : 48-53, 2001