The results of the histopathological observation of uterus and skeletal muscular tissue of castrated female (virgin) rabbits with massive, long-term administration of steroid hormones such as estrogen, testosterone and cortisone are summarized as foll...
The results of the histopathological observation of uterus and skeletal muscular tissue of castrated female (virgin) rabbits with massive, long-term administration of steroid hormones such as estrogen, testosterone and cortisone are summarized as follows.
1. In the castrated group treated with estrogen, the uterine tissue which was generally atrophied by the castration recovered to almost normal or showed rather partial adenomatous proliferation. The skeletal muscie showed mild degenerative changes superimposed by the slight atrophy.
2. Contrary to the finding of noncastrating, testosterone treated group, in which atrophy of endometrial glands and uterine muscles was observed, mild proliferation of endometrial glands and slight atrophy and degeneration of skeletal muscle were seen in castrated particularly 90 days testosterone administered group.
3. The endometrial glands and the uterine muscle fiber showed prominent atrophy in the castrated group treated with cortisone, and in the skeletal muscle degenerative changes, round-cell infiltration and proliferation of connective tissues were evident.
4. The P.A.S. positive substance was increased or decreased in accordance with proliferative or atrophic changes of uterine glands induced by steroid hormones and it is increased in the area where the pathological changes in the skeletal muscle were produced.
5. Slight proliferative changes of endometrial glands were observed by massive, long-term administration of testosterone to the castrated female rabbits while the atrophic change appeared in the noncastrated testosterone treated group.