일측 전정기관 손상 후 전정신경핵의 전기활동성에 대한 항칼슘제의 영향 = Effect of Ca^(2+) Antagonist on Vestibular Nuclear Activities Follwing Unilateral Labyrinthectomy in Rate

다국어 초록 (Multilingual Abstract)

Unilateral labyrinthectomy (ULX) causes vestibular symptoms, such as nausea, vomiting, vertigo spontaneous nystagmus, and head deviation, but some of these symptoms diminish with time in a process of behavioral recovery known as vestibular compensation. In order to investigate the effects of flunarizine and MK-801 on the compensation of vestibuloocular reflex (VOR), spontaneous nystagmus, eye movement induced by sinusoidal rotation of the whole body, and electrical activity of the medial vestibular nuclei were measured following ULX in Sprague-Dawley rats.
Spontaneous nystagmus following ULX disappeared by post-operative 48 hours in control group, by 24 hours in flunarizine treated group, and by 12 hours in MK-801 treated group. On sinusoidal rotation of the whole body at 0.1 ㎐, eye movement induced by rotation toward the lesioned side recovered the normal pattern of VOR after 24 hours in control group, on 12 hours in flunarizine treated group, and on 6 hours in MK-801 treated group. Also, directional preponderance of VOR decreased to less than 20% by 48 hours in control group and in flunarizine treated group, and by24 hours in MK-801 treated group. Field potential evoked by stimulation of the vestibular system was compsed of 3 waves, such as P, N1, N2 wave, whose amplitude was decreased by flunarizine or MK-801. Sontaneous actitivy in the medial vestibular nuclei was suppressed by flunarizine or MK-801, however, the activity of ipsilateral type 1 cell decreased by ULX was increased by MK-801.
These results suggest that flunarizine or MK-801 acting on the intact vestibular nuclei as well as the lesioned muclei ameliorates the compensation of VOR following ULX by accomplishing the symmetry of electrical activities in the bilateral vestibular nuclei.

목차 (Table of Contents)

• 목차
• Ⅶ. 도목차
• ABSTRACT
• Ⅰ. 서론 = 1
• Ⅱ. 실험방법 = 3
• Ⅲ. 실험성적 = 5
• Ⅳ. 고안 = 8
• Ⅴ. 결론 = 11
• Ⅵ. 참고문헌 = 12