Metastatic leiomyosarcoma of the thyroid gland: cytologic findings and differential diagnosis

다국어 초록 (Multilingual Abstract)

Metastatic leiomyosarcoma to the thyroid is an extremely rare occurrence, and only 18 cases have been reported. Here, we report a case of a 37-year-old woman who presented with multiple masses on the scalp. Excisional biopsy was done and the mass revealed fascicles of smooth muscle fibers which showed positive staining for smooth muscle actin, thus confirming the diagnosis of leiomyosarcoma. The patient was also found to have a 0.9 cm mass within the left thyroid. Fine-needle aspiration was done and the cytological smear showed hypercellular spindle cell clusters with hyperchromatic and large nuclei. Normal thyroid follicular cells were found within or around tumor cells. In this report, we present the cytologic findings of metastatic leiomyosarcoma to the thyroid and offer differential diagnoses of the aspirated spindle cells.

참고문헌 (Reference)

1 Gauthe M, "Uterine leiomyosarcoma metastatic to thyroid shown by(18)F-FDG PET/CT imaging" 36 : 113-115, 2017

2 Leath CA 3rd, "Uterine leiomyosarcoma metastatic to the thyroid" 100 : 1122-1124, 2002

3 Golovko A, "Thyroid metastasis of vaginal leiomyosarcoma : a case report and review of the literature" 42 : 242-244, 2020

4 Woo Young K, "Pulmonary leiomyosarcoma metastatic to the thyroid gland : case report and review of the literature" 72 : 314-316, 2011

5 D’Andrea N, "Pulmonary artery leiomyosarcoma with thyroid metastases" 59 : 304-307, 2003

6 Papi G, "Primary spindle cell lesions of the thyroid gland: an overview" 125 (125): S95-S123, 2006

7 Giannikaki E, "Metastatic uterine leiomyosarcoma coexisting with papillary carcinoma of the thyroid gland" 16 : 442-445, 2006

8 Sanchez B, "Metastatic malignant peripheral nerve sheath tumor to the thyroid" 1 : 18-23, 2015

9 Wang TY, "Metastatic leiomyosarcoma of the thyroid : a case report" 61 : 353-357, 1998

10 Eloy JA, "Metastasis of uterine leiomyosarcoma to the thyroid gland : case report and review of the literature" 17 : 1295-1297, 2007

11 Deng XR, "Metastasis of leiomyosarcoma to the thyroid" 118 : 174-176, 2005

12 Michelow PM, "Metastases to the thyroid gland : diagnosis by aspiration cytology" 13 : 209-213, 1995

13 Gross E, "Leiomyosarcoma of the saphenous vein" 116 : 37-41, 1975

14 Nemenqani D, "Leiomyosarcoma metastatic to the thyroid diagnosed by fine needle aspiration cytology" 60 : 307-309, 2010

15 Bode-Lesniewska B, "Leiomyosarcoma in the thyroid gland : primary tumor or metastasis?" 15 : 303-307, 1994

16 Tong GX, "Fine-needle aspiration biopsy of monophasic variant of spindle epithelial tumor with thymus-like differentiation of the thyroid : report of one case and review of the literature" 35 : 113-119, 2007

17 Gattuso P, "Fine needle aspiration cytology of metastatic sarcoma involving the thyroid" 82 : 1158-1160, 1989

18 Vankalakunti M, "Cytology of sarcoma metastasizing to the thyroid : a case report" 52 : 729-732, 2008

19 Chen H, "Clinically significant, isolated metastatic disease to the thyroid gland" 23 : 177-180, 1999

20 Irizarry-Villafane G, "A rare case of uterine leiomyosarcoma with metastasis to the thyroid gland" 2020 : 8889843-, 2020