황금약침액(黃芩藥鍼液)이 가토(家兎) 신피질절편(腎皮質切片)에서 수은(水銀)에 의한 세포막(細胞膜) 물질이동(物質移動) 기능장애(機能障碍)에 미치는 영향(影響) = Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices

다국어 초록 (Multilingual Abstract)

This study was undertaken to determine whether Scutellaria baicalensis Georgi (SbG) extract exerts the protective effect against $HgCl_2$-induced alterations in membrane transport function in rabbit renal cortical slices. The slices were treated with 0.1 mM $HgCl_2$ for 60 min at $37^{\circ}C$. $HgCl_2$ caused an inhibition in PAH uptake by renal cortical slices. Such an effect was accompanied by depressed $Na^+-K^+$-ATPase activity and ATP depletion. SbG prevented $HgCl_2$-induced inhibition of PAH uptake in a dose-dependent manner at the concentration ranges of 0.01-0.1%. $HgCl_2$-induced inhibition of $Na^+-K^+$-ATPase activity and ATP depletion were significantly prevented by 0.05% SbG. These results suggest that SbG prevents $HgCl_2$-induced alterations in membrane transport function in rabbit renal cortical slices. Such protective effects of SbG may be attributed to inhibition of peroxidation of membrane lipid.