姙娠中毒症 患者의 血漿 內 β-thromboglobulin値에 關한 硏究 = Maternal Plasma β-thromboglobulin Concentration in Pre-eclampsia

국문 초록 (Abstract)

妊娠中毒症 患者에 있어서 血小板의 活性度를 觀察함으로써 姙娠中毒症의 病態에 關與 可能性을 알기 위한 目的으로 姙娠中毒症 患者 34例를 對象으로 하여 血小板 活性時 放出되는 β-thromboglobulin의 血漿 內 濃度를 測定하고 正常 妊婦의 그것과 比較, 檢討하였다.

다국어 초록 (Multilingual Abstract)

Abnormal activation of the coagulation system in pre-eclampsia is well documented.
But there have been few studies about platelets which play an important role in the hemostatic system.
Therefore, in order to study the role of platelets in the pathogenesis of pre-eclampsia, we measured the plasma concentrations of β -TG, platelet specific protein that was released during aggregation, using a specific radioimmunoassay in groups of women suffered from mild and severe pre-eclampsia and compared with normal pregnant control.
The results were as follows ;
1) The mean plasma β -TG levels of normal pregnant controls and preeclampsia group were 77.3± 19.07ng/ml and 111.2±52.6 ng/ml respectively. The level of pre-eclampsia group was higher than that of normal pregnant controls significantly.
2) The mean plasma β -TG levels of mild and severe pre-eclampsia groups were 94.3±52.5 ng/ml and 123.0±50.7 ng/ml respectively. The level of severe pre-eclampsia group was higher than that of mild pre-eclampsia group, but there was no significant difference between the two groups.
3) There was no significant difference between mild preeclampsia group and normal pregnant controls.
In pre-eclamptic patients, platelets are in a hyperactive state and rapidly destroyed. This may be involved in the pathogenesis of pre-eclampsia.

목차 (Table of Contents)

• Ⅰ.緖論
• Ⅱ.硏究對象 및 方法
• 1.硏究 對象
• 2.硏究 方法
• Ⅲ.硏究 成績
• 1.硏究 對象의 臨床 特徵
• 2.血漿 內 β-TG値
• Ⅳ.考按
• Ⅴ.結論