소아청소년기의 두개 외 생식세포종양 = Overview of Pediatric Extracranial Germ Cell Tumors

다국어 초록 (Multilingual Abstract)

Germ cell tumors the designation given to neoplasm arising from the cells of the germline, the cells that are destined to become either the egg or the sperm. These tumors have a number of unique features that includes bimodal and wide age distribution, remarkable phenotypic diversity, and varying biologic behavior. During infancy, sacrococcygeal locations predominate with either teratomas in neonates or endodermal sinus tumors in infants above three months. After puberty, non-germinomatous germ cell tumors predominate with gonadal, mediastinal or intracranial tumor. Specific subtypes of germ cell tumors secrete proteins as tumor markers. Surgical resection of the tumor is necessary to establish the diagnosis and for staging of the extent of tumor spread. Except for teratoma, germ cell tumors are highly sensitive to chemotherapy in particular cisplatin. The most commonly used chemotherapy regimen for malignant germ cell tumors is PEB (cisplatin, etoposide and bleomycin). Prognosis is good even in metastatic diseases. Patients with relapsed or recurrent disease may be candidates for high dose chemotherapy and autologous hematopoietic stem cell transplantation.

참고문헌 (Reference)

1 Schneider DT, "Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96" 19 : 1951-1960, 2001

2 Rogers PC, "Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: A Pediatric Intergroup Study-Pediatric Oncology Group 9048 and Children's Cancer Group 8891" 22 : 3563-3569, 2004

3 Bastos DA, "The role of high-dose chemotherapy in the management of germ cell tumors" 26 : 284-293, 2014

4 Rescorla F, "The effect of cisplatin dose and surgical resection in children with malignant germ cell tumors at the sacrococcygeal region: a pediatric intergroup trial (POG 9049/CCG 8882)" 36 : 12-17, 2001

5 Göbel U, "Teratomas in infancy and childhood" 31 : 8-15, 1998

6 Billmire DF, "Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Children's Oncology Group" 32 : 465-470, 2014

7 Toner GC, "Serum tumor marker half-life during chemotherapy allows early prediction of complete response and survival in nonseminomatous germ cell tumors" 50 : 5904-5910, 1990

8 Hartmann JT, "Second-line chemotherapy in patients with relapsed extragonadal nonseminomatous germ cell tumors: results of an international multicenter analysis" 19 : 1641-1648, 2001

9 Chieffi P., "Recent advances in molecular and cell biology of testicular germ-cell tumors" 312 : 79-100, 2014

10 Cushing B, "Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study--Pediatric Oncology Group 9049 and Children's Cancer Group 8882" 22 : 2691-2700, 2004

11 Weissbach L, "Prognostic factors in seminomas with special respect to HCG: results of a prospective multicenter study. Seminoma Study Group" 36 : 601-608, 1999

12 Schneider DT, "Primary mediastinal germ cell tumors in children and adolescents: results of the German cooperative protocols MAKEI 83/86, 89, and 96" 18 : 832-839, 2000

13 Isaacs H Jr., "Perinatal (fetal and neonatal) germ cell tumors" 39 : 1003-1013, 2004

14 Faure-Conter C, "Pediatric germ cell tumours" 100 : 381-391, 2013

15 Kaatsch P, "Pediatric germ cell tumors from 1987 to 2011: incidence rates, time trends, and survival" 135 : e136-e143, 2015

16 De Backer A, "Ovarian germ cell tumors in children: a clinical study of 66 patients" 46 : 459-464, 2006

17 Fraizier AL, "Oncology of infancy and childhood" Saunders Elsvier 911-961, 2009

18 Smith HO, "Incidence and survival rates for female malignant germ cell tumors" 107 : 1075-1085, 2006

19 Heifetz SA, "Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children's Cancer Group" 22 : 1115-1124, 1998

20 Norris HJ, "Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58cases" 37 : 2359-2372, 1976

21 Ezeh UI, "Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma" 104 : 2255-2265, 2005

22 Weissbach L, "Germinal testicular tumors in childhood. Report of observations and literature review" 10 : 73-85, 1984

23 Schneider DT, "Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols" 42 : 169-175, 2004

24 Kondagunta GV, "Combination of paclitaxel, ifosfamide, and cisplatin is an effective second-line therapy for patients with relapsed testicular germ cell tumors" 23 : 6549-6555, 2005

25 Hinton S, "Cisplatin, etoposide and either bleomycin or ifosfamide in the treatment of disseminated germ cell tumors: final analysis of an intergroup trial" 97 : 1869-1875, 2003

26 Shitara T, "Choriocarcinoma in children" 15 : 268-269, 1993

27 Frazier AL, "Application of the adult international germ cell classification system to pediatric malignant non-seminomatous germ cell tumors: a report from the Children's Oncology Group" 50 : 746-751, 2008

28 Korea Central Cancer Registry, "Annual report of cancer statistics in Korea in 2012" Ministry of Health and Welfare 2014

29 Collinson K, "Age-related biological features of germ cell tumors" 53 : 215-227, 2014

30 Lee SU, "A case of 47, XXY/46, XX/46, XY mosaic klinefelter syndrome with mediastinal germ cell tumor" 14 : 83-88, 2007