한국의 성인에서 사회경제적 수준과 대사증후군 발생율의 연관성 및 성별에 따른 차이

다국어 초록 (Multilingual Abstract)

PURPOSE: Metabolic syndrome is defined as the cluster of the risk factors, such as abdominal obesity, hypertension, diabetes and dyslipidemia. And each component of the metabolic syndrome is also known as a risk factor for cardiovascular disease. South Korea is growing industrially and economically, resulting in a tendency also to increase the occurrence of the metabolic syndrome. But the studies of metabolic syndrome in Korea had been mostly cross-sectional study. And the study of the association between the incidence of metabolic syndrome and socioeconomic status is scarce. Therefore, in this study, an association between the incidence of metabolic syndrome and socioeconomic status according to gender was evaluated in Korean middle-aged population.
MATERIALS and METHODS: The large community-based cohort, the Korean Genome and Epidemiology Study (KoGES), was used to analysis. The baseline study was executed from June 2001 to January 2003, and a follow-up survey conducted every two years. This study was based on the results of analysis during the 8-year follow-up period. The study included 5,544 subjects (2,733 men and 2,811 women) aged 40-69 years without metabolic syndrome, diabetes, and history of cardiovascular disease at baseline. To evaluate the relationship between socioeconomic status and metabolic syndrome, subjects were divided into four groups according to their level of education: less than primary school, middle school, high school, and college graduate or higher. Also, they were divided into four categories, based on the monthly household income(10,000 won): less than 100, 100-199, 200-399 and more than 400. Cox regression analysis was performed to determine the relationship between the metabolic syndrome and socioeconomic status.
RESULT: Cumulative incidence of metabolic syndrome is 31.4% (31.6% in men, 31.1% in women) during the mean follow-up period of 6.01 years. The incidence of metabolic syndrome increased according to age increased in women, but not in men. Drinking and smoking in men and exercise in women was associated with the incidence of metabolic syndrome. After adjusting for common risk factors, the hazard ratios (HRs) of incidence of metabolic syndrome for those who in high, middle, and elementary school in education level compared to college graduate or higher group (referent) were 1.10 (95% CI, 0.91-1.32), 1.21 (0.98-1.50), and 1.14 (0.89-1.46) in men, 1.07 (0.76-1.51), 1.73 (1.23-2.44), and 1.74 (1.23-2.46) in women, respectively. And compared to more than 400 (10,000 won) group (referent), HRs for incidence of metabolic syndrome according to the income level is 1.00 (0.78-1.28), 1.23 (0.95-1.58), and 1.44 (1.09-1.92) in men, 1.56 (1.06-2.29), 1.86 (1.28-2.71), and 2.74 (1.87-4.00) in women, respectively. As the results show the association between socioeconomic status and incidence of metabolic syndrome was significant in women, but not in men.
CONCLUSION: Drinking and smoking were associated with the incidence of metabolic syndrome in men and exercise in women. The association between the incident metabolic syndrome and socioeconomic status was revealed in women only in middle-aged Korean.

목차 (Table of Contents)

• Ⅰ. 서 론 1
• 1. 연구배경 및 목적 1
• Ⅱ. 연구방법 5
• 1. 연구대상 5
• 2. 변수의 정의 및 측정방법 8
• 3. 통계적 분석방법 10
• Ⅲ. 연구결과 11
• 1. 대상자의 일반적 특성 11
• 2. 대사증후군의 누적발생율 14
• 3. 대사증후군의 평균 발생율 및 사회경제적 수준과의 연관성 17
• 4. 대사증후군의 구성요소와 사회경제적 수준과의 연관성 20
• 5. 대사증후군의 구성요소 개수와 교육수준 및 소득수준과의 연관성 35
• Ⅳ. 고 찰 38
• Ⅴ. 결 론 42
• 참고문헌 43