위암에 대한 전자현미경적 연구 = Ultrastuctural Study of Gastric Carcinoma

다국어 초록 (Multilingual Abstract)

The histologic classifications of gastric cancer presently used in clinicopathologic studies are two main groups: The intestinal type including papillary adenocarcinoma and well differentiated tubular adenocracinoma, and the diffuse type including signet ring cell carcinoma and poorly differentiated adenocarcinoma. However, ultrastructural studies seem to confirm the occurrence of different cell types in gastric cancer. It may be expected that charaeterization of the various cell types composing gastric cancer and their correlation with known histologic patterns will prove of help in routine diagnostic work. Thus, we investigated 40 gastric cancer, 10 gastric adenoma, and 20 metaplastic gastritis with histopathologic techniques as well as with electron microscopy. Ultrastructural differences were found, implicating microvilli, mucous granules, interdigitations, ribosomes, mitochondria and nuclei.
The results obtained were as follows: 1) In the metaplastic gastritis, more or less regular microvilli with cytoplasmic rootlets of filaments and gastric foveolar granules with punctate-cerebroid inner structure were observed. 2) In the tubular adenoma, the cytoplasm had many large mitochondria and numerous polyribosomes. Junctional complexes and interdigitations were noted. The cells were polygonal in shape and contained nuclei with prominent nucleoli. Multiform, irregularly and sparsely arranged microvilli were observed. Varied mucous granules were noted. 3) In the intestinal type adenocarcinoma, abnormal microvilli with unusually long core filaments which penetrated deeply into the cytoplasm were observed. The junctional complex and interdigitations were poorly developed. 4) In the signet ring cell carcinoma, gablet cell type with homogenous and low density granules were seen. 5) In the signet ring cell carcinoma, intestinal absorptive cell type with an intracellular microcyst lined by microvilli with a filamentous core.