단핵구 및 T 임파구에 대한 Somatostatin의 면역조절 반응 = Immunoregulatory action of somatostatin on mononudear cells & T lymphocytes

다국어 초록 (Multilingual Abstract)

The proliferation of phytohenfagglutinin(PHA)-stimulated human monouclear cells and T lymphocytes in vitro was inhibited significantly from 10^-13 to ^-8M xomatostatin and 10^-12 to 10^-10M somatiostatin respectively as assessed by the uptake of [^3H] thymidine. The activity of PHA-stimulated T lymphocyte was increased by somatostatin in concetration from 10^-8M to 10^-7M. [^3H] thymidine uptake of T lymphocytes was decreased by 10^-12 and 10^-11M somatostatin, and was increased by somatostatin 10^-9 to 10^-7M. Mononuclear cells were stimulated in 10^-12M somatostatin. By the [^3H] deoxygoucose uptake test, PHA-stimulated mononuclear cells were inhibited by any concentrations of somatostatin and PHA-somatostatin T lymphocytes were stimulated in somatostatin 10^-8 & 10^-7M, also But, both the unstimulated mononuclear cells and lymphocytes were revealed decreased [^3H] deosyglucose uptake in somatostatin 10^-13 & 10^-12M.
In conclusion, above experimental data suggested that somatostatin had bidirectional action on modulation of mononuclear cells and T Lymphocytes in immune reaction.