Inclusion complex formation of octyldimethl p-aminobenzoate with β-cyclodextrin in aqueous solution and in the solid state was studied by the solubility method, spectroscopic(UV, FT-IR) and X-ray diffractometry.
The solid complex of octyldimethy p-am...
Inclusion complex formation of octyldimethl p-aminobenzoate with β-cyclodextrin in aqueous solution and in the solid state was studied by the solubility method, spectroscopic(UV, FT-IR) and X-ray diffractometry.
The solid complex of octyldimethy p-aminobenzoate with p-cyclodextrin was obtained in molar ratio of 1 : 2(guest/host). A spatial relationship between host and guest molecule was clearly reflected in the magnitude of the apparent stability constant (K') and in the stoichiometry of the inclusion complex.
Furthermore, a typical type Bs phase-solubility diagram was obtained for octyldimethyl p-aminobenzoate and β-cyclodextrin in water at 25℃.
The results indicated that the solubility of the guest molecule was higher by the formation of β-cyclodextrin inclusion complex