Formulation development and pharmacological evaluation of fxed dose combination of Bombyx mori extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats

다국어 초록 (Multilingual Abstract)

The present study aims at formulation development and pharmacological evaluation of fxed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats.
Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes focculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori extract, Flaxseed oil, CoQ10 and its fxed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and signifcantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profle (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters— SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy.
These results were also confrmed by histopathology. The results of this study strongly indicate the cardioprotective efect of fxed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity.

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